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J-GLOBAL ID：201802263588429161   Reference number：18A0256267

Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells

Wnt阻害剤における加齢に関連した増加はヒト心臓幹細胞の老化様表現型を引き起こす【Powered by NICT】

Author (11)： Nakamura Tamami (Department Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan) ,  Hosoyama Tohru (Department Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan) ,  Hosoyama Tohru (Regenerative Medicine Institute, Yamaguchi University Graduate School of Medicine, Japan) ,  Murakami Junichi (Department Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan) ,  Samura Makoto (Department Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan) ,  Ueno Koji (Department Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan) ,  Kurazumi Hiroshi (Department Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan) ,  Kurazumi Hiroshi (Department of Surgery, Saiseikai Yamaguchi Hospital, Japan) ,  Suzuki Ryo (Department Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan) ,  Mikamo Akihito (Department Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan) ,  Hamano Kimikazu (Department Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 487  Issue： 3  Page： 653-659  Publication year： 2017 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Aging of cardiac stem/progenit...

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Thesaurus term： cardiac insufficiency ,  *senile change ,  *Phenotype ,  therapy ,  *Heart ,  *human ,  therapeutic planning ,  gene ,  Proteins ,  antitumor drug ,  gene expression ,  patient ,  Aged patient ,  committed stem cell ,  *Wnt Proteins ,  molecular genetic phenomenon

Author keywords (6)： Human cardiac stem cells ,  Cardiosphere-derived cells ,  Wnt signaling ,  Secreted frizzled-related protein ,  Senescence ,  Stem cell aging

JST classification (2)： Gene expression  (EC02040Q) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Terms in the title (7)： Wnt ,  阻害剤 ,  加齢 ,  ヒト ,  心臓幹細胞 ,  老化 ,  表現型