Art

J-GLOBAL ID：201802264128065271   Reference number：18A0618227

Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice

アンギオテンシン受容体遮断薬イルベサルタンはマウスにおけるAT1aシグナル伝達とACE2依存性機構を介してストレス誘導性腸炎を減少させる【Powered by NICT】

Author (12)： Yisireyili Maimaiti (Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Yisireyili Maimaiti (Department of Minimally Invasive Hernia and Abdominal Wall Surgery, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, Xinjiang Uygur Autonomous Region, China) ,  Uchida Yasuhiro (Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Yamamoto Koji (Department of Transfusion Medicine and Cell Therapy, Saitama Medical Centre, Saitama Medical University, Kawagoe, Japan) ,  Nakayama Takayuki (Department of Blood Transfusion, Aichi Medical University Hospital, Nagakute, Japan) ,  Cheng Xian Wu (Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Matsushita Tadashi (Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan) ,  Matsushita Tadashi (Department of Blood Transfusion, Nagoya University Hospital, Nagoya, Japan) ,  Nakamura Shigeo (Department of Pathology, Nagoya University Hospital, Nagoya, Japan) ,  Murohara Toyoaki (Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Takeshita Kyosuke (Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Takeshita Kyosuke (Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan)
Material： Brain, Behavior, and Immunity  (Brain Behavior and Immunity)
Volume： 69  Page： 167-179  Publication year： 2018 
JST Material Number： W1766A  ISSN： 0889-1591  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Stress is associated with path...

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Thesaurus term： irritable bowel syndrome ,  anti-inflammatory action ,  *receptor ,  Mammalia ,  Microbiome ,  oral administration ,  pathophysiology ,  active oxygen ,  Up-Regulation ,  Metabolism ,  *angiotensin antagonist ,  immobilization stress ,  *Angiotensin-converting Enzyme 2 ,  Vertebrata ,  amino acid ,  nitrogen heterocyclic compound ,  polynuclear aromatic compound ,  primary amine ,  alicyclic compound ,  aromatic compound ,  lactam ,  spiro-compound

Author keywords (6)： Stress ,  Intestinal inflammation ,  Micro-biota ,  Renin-angiotensinogen system ,  Reactive oxygen species ,  Tryptophan metabolism

JST classification (1)： Basic medicine on digestive system  (GH01020E)

Substance index (2)： Tryptophan ,  Irbesartan

Terms in the title (8)： アンギオテンシン受容体遮断薬 ,  イルベサルタン ,  マウス ,  シグナル伝達 ,  ACE2 ,  依存性 ,  ストレス ,  腸炎