Art

J-GLOBAL ID：201802264579749313   Reference number：18A0364724

Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells

アミノ酸輸送体SLC15A4により調節されるリソソームの生合成は,肥満細胞の機能的完全性に重要である

Author (10)： KOBAYASHI Toshihiko (National Center for Global Health and Medicine, Tokyo, JPN) ,  TSUTSUI Hidemitsu (National Center for Global Health and Medicine, Tokyo, JPN) ,  SHIMABUKURO-DEMOTO Shiho (National Center for Global Health and Medicine, Tokyo, JPN) ,  YOSHIDA-SUGITANI Reiko (National Center for Global Health and Medicine, Tokyo, JPN) ,  KARYU Hitomi (National Center for Global Health and Medicine, Tokyo, JPN) ,  FURUYAMA-TANAKA Kaori (National Center for Global Health and Medicine, Tokyo, JPN) ,  OHSHIMA Daisuke (National Center for Global Health and Medicine, Tokyo, JPN) ,  KATO Norihiro (National Center for Global Health and Medicine, Tokyo, JPN) ,  OKAMURA Tadashi (National Center for Global Health and Medicine, Tokyo, JPN) ,  TOYAMA-SORIMACHI Noriko (National Center for Global Health and Medicine, Tokyo, JPN)
Material： International Immunology  (Int Immunol)
Volume： 29  Issue： 12  Page： 551-566  Publication year： Dec. 2017 
JST Material Number： W0116A  ISSN： 0953-8178  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： Membrane Proteins ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (4)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Function of cell components  (EF03060C) ,  Immunological reaction in general  (ED03010T) ,  Cell physiology in general  (EF02010S)

Reference (53)：

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• Blasius, A. L., Arnold, C. N., Georgel, P.et al. 2010. Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc. Natl Acad. Sci. USA 107:19973.
• Lee, J.,Tattoli, I.,Wojtal, K. A.,Vavricka, S. R.,Philpott, D. J. and Girardin, S. E. 2009. pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J. Biol. Chem . 284:23818.
• Blasius, A. L.,Krebs, P.,Sullivan, B. M.,Oldstone, M. B. and Popkin, D. L. 2012. Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection. PLoS Pathog . 8:e1002915.

Terms in the title (6)： アミノ酸輸送体 ,  調節 ,  リソソーム ,  生合成 ,  肥満細胞 ,  完全性