Art

J-GLOBAL ID：201802265570690187   Reference number：18A1367132

Efficacy and Safety of Trastuzumab in Combination with S-1 and Cisplatin Therapy for Japanese Patients with HER2-Positive Advanced Gastric Cancer: Retrospective Analysis

日本人のHER2陽性進行胃癌患者に対するS-1およびシスプラチン療法と併用したトラスツズマブの有効性と安全性: 後ろ向き分析

Author (33)： Okita Akira (Department of Medical Oncology, Tohoku University Hospital) ,  Okita Akira (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Imai Hiroo (Department of Medical Oncology, Tohoku University Hospital) ,  Imai Hiroo (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Takahashi Masahiro (Department of Medical Oncology, Tohoku University Hospital) ,  Takahashi Masahiro (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Takahashi Hidekazu (Department of Medical Oncology, Ishinomaki Red Cross Hospital) ,  Umegaki Sho (Department of Medical Oncology, Tohoku University Hospital) ,  Umegaki Sho (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Kawamura Yoshifumi (Department of Medical Oncology, Tohoku University Hospital) ,  Kawamura Yoshifumi (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Hiraide Sakura (Department of Medical Oncology, Tohoku University Hospital) ,  Hiraide Sakura (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Ouchi Kota (Department of Medical Oncology, Tohoku University Hospital) ,  Ouchi Kota (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Sato Yuko (Department of Medical Oncology, Tohoku University Hospital) ,  Sato Yuko (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Okada Yoshinari (Department of Medical Oncology, Tohoku University Hospital) ,  Okada Yoshinari (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Komine Keigo (Department of Medical Oncology, Tohoku University Hospital) ,  Komine Keigo (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Saijo Ken (Department of Medical Oncology, Tohoku University Hospital) ,  Saijo Ken (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Takahashi Shin (Department of Medical Oncology, Tohoku University Hospital) ,  Takahashi Shin (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Takahashi Masanobu (Department of Medical Oncology, Tohoku University Hospital) ,  Takahashi Masanobu (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Shirota Hidekazu (Department of Medical Oncology, Tohoku University Hospital) ,  Shirota Hidekazu (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University) ,  Ohori Hisatsugu (Department of Medical Oncology, Ishinomaki Red Cross Hospital) ,  Gamoh Makio (Department of Medical Oncology, Osaki Citizen Hospital) ,  Ishioka Chikashi (Department of Medical Oncology, Tohoku University Hospital) ,  Ishioka Chikashi (Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University)
Material： Tohoku Journal of Experimental Medicine  (Tohoku J Exp Med)
Volume： 245  Issue： 2  Page： 123-129(J-STAGE)  Publication year： 2018 
JST Material Number： G0649A  ISSN： 0040-8727  CODEN： TJEMAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *cisplatin ,...

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Author keywords (5)： chemotherapy ,  gastric cancer ,  HER2 ,  S-1 ,  trastuzumab

JST classification (2)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Tumors(=neoplasms)of digestive system  (GH04000D)

Substance index (1)： TS-1

Reference (25)：

• Bang, Y.J., Van Cutsem, E., Feyereislova, A., Chung, H.C., Shen, L., Sawaki, A., Lordick, F., Ohtsu, A., Omuro, Y., Satoh, T., Aprile, G., Kulikov, E., Hill, J., Lehle, M., Rüschoff, J., et al. (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet, 376, 687-697.
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• Fujitani, K., Yang, H.K., Mizusawa, J., Kim, Y.W., Terashima, M., Han, S.U., Iwasaki, Y., Hyung, W.J., Takagane, A., Park, D.J., Yoshikawa, T., Hahn, S., Nakamura, K., Park, C.H., Kurokawa, Y., et al. (2016) Gastrectomy plus chemotherapy versus chemotherapy alone for advanced gastric cancer with a single non-curable factor (REGATTA): a phase 3, randomised controlled trial. Lancet Oncol., 17, 309-318.

Terms in the title (11)： 日本人 ,  HER2陽性進行胃癌 ,  患者 ,  S-1 ,  シスプラチン ,  療法 ,  併用 ,  トラスツズマブ ,  有効性 ,  安全性 ,  後ろ向き分析