Art

J-GLOBAL ID：201802266060805697   Reference number：18A0776951

Highly Diastereoselective Synthesis of 2-(1-N-Boc-aminoalkyl)thiazole-5-carboxylates by Reduction of tert-Butylsulfinyl Ketimines

tert-ブチルスルフィニルケチミンの還元による2-(1-N-Boc-アミノアルキル)チアゾール-5-カルボキシレートの高度ジアステレオ選択的合成

Author (10)： Magata Takuji (Faculty of Pharmacy, Osaka Ohtani University) ,  Hirokawa Yoshimi (Faculty of Pharmacy, Osaka Ohtani University) ,  Furokawa Aya (Faculty of Pharmacy, Osaka Ohtani University) ,  Takeuchi Kazuhisa (Faculty of Pharmacy, Osaka Ohtani University) ,  Ohtomo Yoshiaki (Faculty of Pharmacy, Osaka Ohtani University) ,  Kino Toshitaka (Faculty of Pharmacy, Osaka Ohtani University) ,  Kominami Jun (Faculty of Pharmacy, Osaka Ohtani University) ,  Nakai Yuto (Faculty of Pharmacy, Osaka Ohtani University) ,  Kitamura Maria (Faculty of Pharmacy, Osaka Ohtani University) ,  Maezaki Naoyoshi (Faculty of Pharmacy, Osaka Ohtani University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 66  Issue： 4  Page： 416-422(J-STAGE)  Publication year： 2018 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： stereoselectivity ,  *diastereomer ,  structural isomer ,  *imine ,  *catalytic reduction ,  conformational energy ,  stereochemistry ,  potassium compound ,  borate
Semi thesaurus term： *ketimine ,  potassium tetraborate

Author keywords (6)： thiazole amino acid ,  N-tert-butylsulfinyl ketimine ,  L-Selectride ,  thiazole amino acid ,  N-tert-butylsulfinyl ketimine ,  L-Selectride

JST classification (1)： Stereochemistry of organic reaction  (CF02130V)

Substance index (10)： L-Selectride ,  2-[(S)-1-[(tert-Butylsulfinyl)amino]ethyl]thiazole-5-carboxylic acid ethyl ester ,  2-[(S)-1-(tert-Butylsulfinylamino)-2-methylpropyl]thiazole-5-carboxylic acid ethyl ester ,  2-[(S)-1-[(tert-Butylsulfinyl)amino]-2-phenylethyl]thiazole-5-carboxylic acid ethyl ester ,  2-[(S)-Cyclohexyl[(tert-butylsulfinyl)amino]methyl]thiazole-5-carboxylic acid ethyl ester ,  2-[(S)-1-[(tert-Butyloxycarbonyl)amino]ethyl]thiazole-5-carboxylic acid ethyl ester ,  2-[(S)-1-(tert-Butoxycarbonylamino)-2-methylpropyl]thiazole-5-carboxylic acid ethyl ester ,  2-[(S)-1-[(tert-Butyloxycarbonyl)amino]-2-phenylethyl]thiazole-5-carboxylic acid ethyl ester ,  2-[(S)-Cyclohexyl[(tert-butyloxycarbonyl)amino]methyl]thiazole-5-carboxylic acid ethyl ester ,  2-Methylpropane-2-sulfinamide

Reference (31)：

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Terms in the title (7)： TERT ,  還元 ,  アミノアルキル ,  チアゾール ,  カルボキシレート ,  高度 ,  ジアステレオ選択