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J-GLOBAL ID：201802266743914302   Reference number：18A0339395

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking

左右対称性の破れのためのPCP蛋白質結節細胞を分極を介してWnt5活性非対称性と細胞間シグナル伝達【Powered by NICT】

Author (24)： Minegishi Katsura (Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Minegishi Katsura (Laboratory for Organismal Patterning, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Hashimoto Masakazu (Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Ajima Rieko (Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Ajima Rieko (Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, MD 21702, USA) ,  Takaoka Katsuyoshi (Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Shinohara Kyosuke (Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Ikawa Yayoi (Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Ikawa Yayoi (Laboratory for Organismal Patterning, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Nishimura Hiromi (Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Nishimura Hiromi (Laboratory for Organismal Patterning, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  McMahon Andrew P. (Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA) ,  Willert Karl (Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA) ,  Okada Yasushi (Laboratory for Cell Polarity Regulation, RIKEN Quantitative Biology Center, 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan) ,  Sasaki Hiroshi (Laboratory for Embryogenesis, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Shi Dongbo (Division of Embryology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan) ,  Fujimori Toshihiko (Division of Embryology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan) ,  Ohtsuka Toshihisa (Department of Biochemistry, Faculty of Medicine/Graduate School of Medicine, University of Yamanashi, 1110 Shimo-Kato, Chuo, Yamanashi 409-3898, Japan) ,  Igarashi Yasunobu (Advanced Software Development Department, OLYMPUS Software Technology Corporation, 2-3 Kuboyama-cho, Hachioji-shi, Tokyo 192-8512, Japan) ,  Yamaguchi Terry P. (Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, MD 21702, USA) ,  Shimono Akihiko (Vertebrate Body Plan Group, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Shiratori Hidetaka (Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Hamada Hiroshi (Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Hamada Hiroshi (Laboratory for Organismal Patterning, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan)
Material： Developmental Cell  (Dev Cell)
Volume： 40  Issue： 5  Page： 439-452.e4  Publication year： 2017 
JST Material Number： W1692A  ISSN： 1534-5807  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Polarization of node cells alo...

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Thesaurus term： polarity ,  gene ,  perturbation ,  wild type ,  *symmetry breaking ,  *asymmetry ,  *polarization(phenomenon) ,  *protein
Semi thesaurus term： *Wnt蛋白質 ,  Prickle1 ,  平面細胞極性 ,  阻害剤 ,  Wntシグナル ,  Wnt5a蛋白質 ,  *結節 , 【Automatic Indexing@JST】

Author keywords (6)： planar cell polarity ,  breaking of left-right symmetry ,  Wnt ,  Sfrp ,  cilia ,  basal body

JST classification (2)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Terms in the title (9)： 左右対称性 ,  PCP ,  蛋白質 ,  結節 ,  細胞 ,  分極 ,  活性 ,  非対称性 ,  シグナル伝達