Art

J-GLOBAL ID：201802268913773793   Reference number：18A1114609

A clinician’s guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms

TRαおよびTRβイソ型における受容体変異による甲状腺ホルモンに対する抵抗性を理解するための臨床医の指針【JST・京大機械翻訳】

Author (2)： Singh Brijesh K. (Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore) ,  Yen Paul M. (Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore)
Material： Clinical Diabetes and Endocrinology (Web)
Volume： 3  Issue： 1  Page： 8  Publication year： 2017 
JST Material Number： U7469A  ISSN： 2055-8260  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： There are two genes that expre...

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Thesaurus term： Phenotype ,  thyroid hormone receptor ,  gene ,  *thyroid hormone ,  Mutation ,  TSH ,  receptor ,  Serum ,  human ,  patient ,  *isoform ,  *Genetic Variation
Semi thesaurus term： *variation(biology) ,  *臨床医 , 【Automatic Indexing@JST】

Author keywords (5)： Resistance to thyroid hormone ,  Thyroid hormone receptors ,  Dominant negative activity ,  Thyroid stimulating hormone ,  Human mutation

JST classification (2)： Basic medicine on endocrine system  (GL01020Q) ,  Endocrine diseases  (GL03000I)

Reference (56)：

• Endocrinology; Pseudohypopara-thyroidism - an example of Seabright's bantam syndrome; F Albright, CH Burnett, PH Smith, W Parson; 30; 1942; 922; CR1;
• Mol Endocrinol; Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance; S Ando, NJ Sarlis, J Krishnan, X Feng, S Refetoff, MQ Zhang, EH Oldfield, PM Yen; 15; 2001; 1529-1538; 10.1210/mend.15.9.0687; CR2;
• J Clin Endocrinol Metab; Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor; S Ando, NJ Sarlis, EH Oldfield, PM Yen; 86; 2001; 5572-5576; CR3;
• PLoS One; Genome-wide binding patterns of thyroid hormone receptor beta; S Ayers, MP Switnicki, A Angajala, J Lammel, AS Arumanayagam, P Webb; 9; 2014; 10.1371/journal.pone.0081186; CR4;
• Mol Cell Endocrinol; Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions; JH Bassett, CB Harvey, GR Williams; 213; 2003; 1-11; 10.1016/j.mce.2003.10.033; CR5;

Terms in the title (9)： TR ,  イソ型 ,  受容体 ,  変異 ,  甲状腺ホルモン ,  抵抗性 ,  理解 ,  臨床医 ,  指針