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J-GLOBAL ID：201802268997525144   Reference number：18A0153537

Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217

AMPKαのノックダウンは,ATM発現を低下させ,SV40で形質転換したヒト線維芽細胞株LM217における低酸素・低栄養で誘導放射線感受性を増加させる【Powered by NICT】

Author (8)： Murata Yasuhiko (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan) ,  Hashimoto Takuma (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan) ,  Urushihara Yusuke (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan) ,  Shiga Soichiro (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan) ,  Takeda Kazuya (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan) ,  Takeda Kazuya (Department of Radiation Oncology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan) ,  Jingu Keiichi (Department of Radiation Oncology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan) ,  Hosoi Yoshio (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 495  Issue： 4  Page： 2566-2572  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Presence of unperfused regions...

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Thesaurus term： *radiosensitivity ,  *fibroblast ,  *oxygen deficiency ,  anoxia ,  HepG2 cell ,  *transformation ,  radiation resistance (radiation effect) ,  *human ,  siRNA ,  molecular mechanism ,  Cell Survival ,  *Cell Line ,  mTORC1 ,  nutrient starvation ,  *AMP-Activated Protein Kinases

Author keywords (7)： Radiosensitivity ,  Starvation ,  Hypoxia ,  ATM ,  AMPK ,  mTOR ,  HIF-1

JST classification (3)： Cell physiology in general  (EF02010S) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Gene expression  (EC02040Q)

Terms in the title (13)： AMPK ,  ノックダウン ,  ATM ,  発現 ,  SV40 ,  形質転換 ,  ヒト ,  線維芽細胞 ,  株 ,  低酸素 ,  低栄養 ,  誘導 ,  放射線感受性