Art

J-GLOBAL ID：201802269725540710   Reference number：18A0991220

An Ethylenediamine-based Switch to Render the Polyzwitterion Cationic at Tumorous pH for Effective Tumor Accumulation of Coated Nanomaterials

被覆ナノ材料の効果的な腫瘍蓄積のための腫瘍pHにおけるポリ双性イオン陽イオンを抑制するためのエチレンジアミンに基づくスイッチ【JST・京大機械翻訳】

Author (12)： Ranneh Abdul-Hackam (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259, Nagatsuta, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan) ,  Takemoto Hiroyasu (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259, Nagatsuta, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan) ,  Sakuma Shunya (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259, Nagatsuta, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan) ,  Awaad Aziz (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259, Nagatsuta, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan) ,  Awaad Aziz (Department of Zoology, Faculty of Science, Sohag University, The University Street, Naser City, Sohag, 82524, Egypt) ,  Nomoto Takahiro (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259, Nagatsuta, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan) ,  Mochida Yuki (Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 212-0821, Japan) ,  Matsui Makoto (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259, Nagatsuta, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan) ,  Tomoda Keishiro (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259, Nagatsuta, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan) ,  Naito Mitsuru (Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Nishiyama Nobuhiro (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, R1-11, 4259, Nagatsuta, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan) ,  Nishiyama Nobuhiro (Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 212-0821, Japan)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 57  Issue： 18  Page： 5057-5061  Publication year： 2018 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Polyzwitterions are employed a...

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Thesaurus term： *tumor ,  protonation ,  macromolecule ,  *zwitterion ,  electric charge ,  *cation ,  quantum dot ,  *covering ,  *switch ,  anion ,  *nanomaterial ,  interaction ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  carboxylate(salt) ,  quaternary ammonium ,  alkylenediamine ,  diamine ,  primary amine
Semi thesaurus term： 生体材料 , 【Automatic Indexing@JST】

Author keywords (5)： betaines ,  net charge ,  pH-responsiveness ,  polymers ,  targeted delivery

JST classification (4)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic biopharmacy  (GY01021U) ,  Inorganic compounds and elements in general  (CD01010D) ,  Molecular compounds  (CE02000C)

Substance index (2)： Betaine ,  Ethylenediamine

Terms in the title (7)： ナノ材料 ,  腫瘍蓄積 ,  腫瘍 ,  pH ,  双性イオン ,  陽イオン ,  エチレンジアミン