Art

J-GLOBAL ID：201802270434725051   Reference number：18A0418296

Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice

マウスにおけるアテローム発生と肢虚血に対するピタバスタチンの内皮一酸化窒素合成酵素非依存的な多面的効果

Author (9)： Mitsuhashi Takeshi (Student Laboratory, Faculty of Medicine, Tokushima University) ,  Uemoto Ryoko (Department of Community Medicine for Diabetes and Metabolic Disorders, Tokushima University) ,  Ishikawa Kazue (Department of Medical Education, Tokushima University) ,  Yoshida Sumiko (Department of Hematology, Endocrinology & Metabolism, Tokushima University) ,  Ikeda Yasumasa (Department of Pharmacology, Tokushima University) ,  Yagi Shusuke (Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences) ,  Matsumoto Toshio (Fujii Memorial Institute of Medical Sciences, Tokushima University) ,  Akaike Masashi (Department of Medical Education, Tokushima University) ,  Aihara Ken-ichi (Department of Community Medicine for Diabetes and Metabolic Disorders, Tokushima University)
Material： Journal of Atherosclerosis and Thrombosis (Web)  (J Atheroscler Thromb (Web))
Volume： 25  Issue： 1  Page： 65-80(J-STAGE)  Publication year： 2018 
JST Material Number： U0153A  ISSN： 1880-3873  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： eNOS ,...

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Author keywords (5)： Pitavastatin ,  Pleiotropic effect ,  Atherogenesis ,  Ischemia ,  eNOS

JST classification (3)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Animal biochemistry  (EJ01050P)

Substance index (1)： Pitavastatin

Reference (49)：

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• 2) Bonetti PO, Lerman LO, Lerman A: Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol, 2003; 23: 168-175
• 3) Madigan M, Zuckerbraun B: Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction. Front Immuno, 2013; 4: 174
• 4) Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J: Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet, 2003; 361: 1149-1158
• 5) Tian J, Gu X, Sun Y, Ban X, Xiao Y, Hu S, Yu B: Effect of statin therapy on the progression of coronary atherosclerosis. BMC Cardiovasc Disord, 2012; 12: 70

Terms in the title (8)： マウス ,  アテローム発生 ,  肢虚血 ,  ピタバスタチン ,  内皮 ,  一酸化窒素合成酵素 ,  非依存 ,  多面的効果