Art

J-GLOBAL ID：201802271302693218   Reference number：18A1010620

Evaluation of pH-sensitive fusogenic polymer-modified liposomes co-loaded with antigen and α-galactosylceramide as an anti-tumor vaccine

抗腫瘍ワクチンとして抗原とα-ガラクトシルセラミドを共担持したpH感受性融合性ポリマー修飾リポソームの評価

Author (4)： OKAZAKI Seiji (Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka 598-8531, Japan) ,  IWASAKI Tadashi (Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka 598-8531, Japan) ,  YUBA Eiji (Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan) ,  WATARAI Shinobu (Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka 598-8531, Japan)
Material： Journal of Veterinary Medical Science (Web)
Volume： 80  Issue： 2  Page： 197-204(J-STAGE)  Publication year： 2018 
JST Material Number： U1094A  ISSN： 1347-7439  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tumor vaccine ,...
Semi thesaurus term： IFN gamma ,...

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Author keywords (5)： cancer immunotherapy ,  α-GalCer ,  liposome ,  pH-sensitive liposome ,  tumor vaccine

JST classification (3)： Basic research of immunotherapeutic agents and blood preparations  (GW22010D) ,  Tumor immunity  (ED03040A) ,  Immunotherapy for tumors  (GE03035B)

Substance index (1)： α-Galactosylceramide

Reference (31)：

• 1. Buckanovich, R. J., Facciabene, A., Kim, S., Benencia, F., Sasaroli, D., Balint, K., Katsaros, D., O’Brien-Jenkins, A., Gimotty, P. A. and Coukos, G. 2008. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nat. Med. 14: 28-36.
• 2. Bülow, R. and Boothroyd, J. C. 1991. Protection of mice from fatal Toxoplasma gondii infection by immunization with p30 antigen in liposomes. J. Immunol. 147: 3496-3500.
• 3. Dudek, A. M., Martin, S., Garg, A. D. and Agostinis, P. 2013. Immature, semi-mature, and fully mature dendritic cells: toward a DC-cancer cells interface that augments anticancer immunity. Front. Immunol. 4: 438.
• 4. Fujii, S., Liu, K., Smith, C., Bonito, A. J. and Steinman, R. M. 2004. The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J. Exp. Med. 199: 1607-1618.
• 5. Fujii, S., Shimizu, K., Okamoto, Y., Kunii, N., Nakayama, T., Motohashi, S. and Taniguchi, M. 2013. NKT cells as an ideal anti-tumor immunotherapeutic. Front. Immunol. 4: 409.

Terms in the title (10)： 腫瘍ワクチン ,  抗原 ,  α-ガラクトシルセラミド ,  担持 ,  pH感受性 ,  融合 ,  ポリマー ,  修飾 ,  リポソーム ,  評価