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J-GLOBAL ID：201802271360122869   Reference number：18A1619825

BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells

BCL2阻害剤ABT-199とJNK阻害剤SP600125はイマチニブ耐性pH+ALL細胞に対する相乗的細胞毒性を示す【JST・京大機械翻訳】

Author (12)： Inoue Chisato (College of Life and Health Sciences, Chubu University, Matsumoto-cho 1200, Kasugai 487-8501, Japan) ,  Sobue Sayaka (College of Life and Health Sciences, Chubu University, Matsumoto-cho 1200, Kasugai 487-8501, Japan) ,  Aoyama Yuka (College of Life and Health Sciences, Chubu University, Matsumoto-cho 1200, Kasugai 487-8501, Japan) ,  Mizutani Naoki (College of Life and Health Sciences, Chubu University, Matsumoto-cho 1200, Kasugai 487-8501, Japan) ,  Kawamoto Yoshiyuki (College of Life and Health Sciences, Chubu University, Matsumoto-cho 1200, Kasugai 487-8501, Japan) ,  Nishizawa Yuji (College of Life and Health Sciences, Chubu University, Matsumoto-cho 1200, Kasugai 487-8501, Japan) ,  Ichihara Masatoshi (College of Life and Health Sciences, Chubu University, Matsumoto-cho 1200, Kasugai 487-8501, Japan) ,  Abe Akihiro (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 461-8560, Japan) ,  Hayakawa Fumihiko (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 461-8560, Japan) ,  Suzuki Motoshi (Division of Molecular Oncology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan) ,  Nozawa Yoshinori (Tokai Gakuin University, Kakamigahara 504-8511, Japan) ,  Murate Takashi (College of Life and Health Sciences, Chubu University, Matsumoto-cho 1200, Kasugai 487-8501, Japan)
Material： Biochemistry and Biophysics Reports
Volume： 15  Page： 69-75  Publication year： 2018 
JST Material Number： W3090A  ISSN： 2405-5808  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Imatinib (IMT), a specific tyr...

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Thesaurus term： phosphorylation ,  *cytotoxicity ,  therapeutic planning ,  Apoptosis ,  sensitivity ,  potentiation ,  apoptosis induction ,  cell propagation depression ,  Cell Line ,  tyrosine kinase inhibitor ,  *imatinib resistance ,  *JNK inhibitor ,  Genetic Variation
Semi thesaurus term： variation(biology) ,  急性リンパ性白血病 ,  *阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Ph+ ALL ,  Imatinib-resistance ,  JNK inhibitor ,  BCL2 inhibitor ,  Synergistic action

JST classification (2)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Terms in the title (6)： Bcl2 ,  阻害剤 ,  ABT-199 ,  JNK阻害剤 ,  イマチニブ耐性 ,  細胞毒性