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J-GLOBAL ID：201802271919846690   Reference number：18A1638688

Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways

STING-I型インターフェロンと腫瘍細胞死経路における二重機能を有する新規化合物SINCRO

Author (12)： Kimura Yoshitaka (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan) ,  Negishi Hideo (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan) ,  Matsuda Atsushi (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan) ,  Endo Nobuyasu (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan) ,  Hangai Sho (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan) ,  Hangai Sho (Center for Integrative Inflammology, Max Planck-The University of Tokyo, Tokyo, Japan) ,  Inoue Asuka (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan) ,  Nishio Junko (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan) ,  Taniguchi Tadatsugu (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan) ,  Taniguchi Tadatsugu (Center for Integrative Inflammology, Max Planck-The University of Tokyo, Tokyo, Japan) ,  Yanai Hideyuki (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan) ,  Yanai Hideyuki (Center for Integrative Inflammology, Max Planck-The University of Tokyo, Tokyo, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 109  Issue： 9  Page： 2687-2696  Publication year： 2018 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *adaptor protein ,...
Semi thesaurus term： type I interferon ,...

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Author keywords (5)： anticancer drug ,  cancer immunity ,  cytotoxicity ,  STING ,  type I interferon

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Tumor immunity  (ED03040A)

Substance index (1)： N-(3-{[1,4’-ビピペリジン]-1’-イル}プロピル)-6-[4-(4-メチルピペラジン-1-イル)フェニル]ピリジン-2-カルボキサミド

Terms in the title (5)： STING ,  I型インターフェロン ,  腫瘍細胞 ,  経路 ,  新規化合物