Art

J-GLOBAL ID：201802272066511147   Reference number：18A0827485

Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate

アルテスネートのpHおよび酸素依存性酸化活性のメカニズム

Author (12)： Tsuda Katsunori (Department of Medical Pharmacology, Institute of Biomedical Sciences, University of Tokushima Graduate School) ,  Miyamoto Licht (Department of Medical Pharmacology, Institute of Biomedical Sciences, University of Tokushima Graduate School) ,  Hamano Shuichi (Department of Cell and Immunity Analytics, Institute of Biomedical Sciences, University of Tokushima Graduate School) ,  Morimoto Yuri (Major in Laboratory Science, School of Health Sciences, Faculty of Medicine, Tokushima University) ,  Kangawa Yumi (Major in Laboratory Science, School of Health Sciences, Faculty of Medicine, Tokushima University) ,  Fukue Chika (Major in Laboratory Science, School of Health Sciences, Faculty of Medicine, Tokushima University) ,  Kagawa Yoko (Major in Laboratory Science, School of Health Sciences, Faculty of Medicine, Tokushima University) ,  Horinouchi Yuya (Department of Pharmacology, Institute of Biomedical Sciences, University of Tokushima Graduate School) ,  Xu Wenting (Department of Medical Pharmacology, Institute of Biomedical Sciences, University of Tokushima Graduate School) ,  Ikeda Yasumasa (Department of Pharmacology, Institute of Biomedical Sciences, University of Tokushima Graduate School) ,  Tamaki Toshiaki (Department of Pharmacology, Institute of Biomedical Sciences, University of Tokushima Graduate School) ,  Tsuchiya Koichiro (Department of Medical Pharmacology, Institute of Biomedical Sciences, University of Tokushima Graduate School)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 4  Page： 555-563(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： Artemisia annua ,...

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Author keywords (10)： artesunate ,  iron ,  reactive oxygen species (ROS) ,  cancer ,  electron paramagnetic resonance (EPR) ,  artesunate ,  iron ,  reactive oxygen species (ROS) ,  cancer ,  electron paramagnetic resonance (EPR)

JST classification (2)： Crude drugs in general  (GX06010Y) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Artesunate ,  Artemisinin

Reference (68)：

• 1) Sherman IW. Biochemistry of Plasmodium (malarial parasites). Microbiol. Rev., 43, 453-495 (1979).
• 2) WHO. “World Malaria Report 2016.”: ‹http://www.who.int/malaria/publications/world-malaria-report-2016/report/en/›.
• 3) WHO. Guidelines for the treatment of malaria. Third edition. (2015).
• 4) Klayman DL. Qinghaosu (artemisinin): an antimalarial drug from China. Science, 228, 1049-1055 (1985).
• 5) Asano M, Iwahashi H. Determination of the structures of radicals formed in the reaction of antimalarial drug artemisinin with ferrous ions. Eur. J. Med. Chem., 127, 740-747 (2017).

Terms in the title (6)： pH ,  酸素 ,  依存性 ,  酸化 ,  活性 ,  メカニズム