Art

J-GLOBAL ID：201802272687116382   Reference number：18A1420678

Pharmaceutical Microcrystal Formation by Supersaturation Control with an Electrolyte

電解質による過飽和制御による医薬品微結晶形成

Author (6)： Kishida Muneki (Process Development Department, Production Technology & Supply Chain Management Division, Mitsubishi Tanabe Pharma Corporation) ,  Kishida Muneki (Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University) ,  Igarashi Koichi (Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University) ,  Azuma Masayuki (Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University) ,  Ooshima Hiroshi (Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University) ,  Ooshima Hiroshi (R&D Center, Kansai Chemical Engineering Co., Ltd.)
Material： Journal of Chemical Engineering of Japan  (J Chem Eng Jpn)
Volume： 51  Issue： 7  Page： 609-614(J-STAGE)  Publication year： 2018 
JST Material Number： S0629A  ISSN： 0021-9592  CODEN： JCEJAQ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *microcrystal ,...
Semi thesaurus term： supersaturated solution ,...

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Author keywords (8)： Particle Size Control ,  Microcrystal ,  Solubility Control ,  Additive ,  Particle Size Control ,  Microcrystal ,  Solubility Control ,  Additive

JST classification (2)： Crystallization  (XD02070T) ,  Physical pharmacy  (GY01012A)

Substance index (1)： Ecabet sodium

Reference (14)：

• Bhamidi, V., E. Skrzypczak-Jankun and C. A. Schall; “Dependence of Nucleation Kinetics and Crystal Morphology of a Model Protein System on Ionic Strength,” J. Cryst. Growth, 232, 77-85 (2001)
• Hagsten, A., C. Casper Larsen, J. Møller Sonnergaard, J. Rantanen and L. Hovgaard; “Identifying Sources of Batch to Batch Variation in Processability,” Powder Technol., 183, 213-219 (2008)
• Hofmeister, F.; “On the Understanding of the Effects of Salts,” Arch. Exp. Pathol. Pharmakol., 24, 247-260 (1888)
• Hrkovac, M., J. P. Kardum and N. Ukrainczyk; “Influence of NaCl on Granulometric Characteristics and Polymorphism in Batch-Cooling Crystallization of Glycine,” Chem. Eng. Technol., 38, 139-146 (2015)
• Igarashi, K., Y. Yamanaka, M. Azuma and H. Ooshima; “Control of Crystal Size Distribution Using a mL-Scale Continuous Crystallizer Equipped with a High Speed Agitator,” J. Chem. Eng. Japan, 45, 28-33 (2012)

Terms in the title (4)： 電解質 ,  過飽和 ,  医薬品 ,  微結晶