Art

J-GLOBAL ID：201802273186595375   Reference number：18A0018810

Expanding the pharmacological profile of κ-hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K_v10.1

κ-hefutoxin1および類似体の薬理学的プロフィルの拡大:発癌性チャネルK_v10 1に対する阻害効果に焦点を当てて【Powered by NICT】

Author (11)： Moreels Lien (Toxicology and Pharmacology, KU Leuven, Campus Gasthuisberg O&N2, Herestraat 49, PO Box 922, 3000 Leuven, Belgium) ,  Peigneur Steve (Toxicology and Pharmacology, KU Leuven, Campus Gasthuisberg O&N2, Herestraat 49, PO Box 922, 3000 Leuven, Belgium) ,  Yamaguchi Yoko (Department of Environmental Science, Fukuoka Women’s University, Fukuoka 813-8529, Japan) ,  Vriens Kim (Centre of Microbial and Plant Genetics, KU Leuven, Kasteelpark Arenberg 20, PO Box 2460, 3001 Leuven, Belgium) ,  Waelkens Etienne (Laboratory of Protein Phosphorylation and Proteomics, KU Leuven, Campus Gasthuisberg, O&N1, Herestraat 49, PO Box 901, 3000 Leuven, Belgium) ,  Zhu Shunyi (Group of Peptide Biology and Evolution, State Key Laboratory of Integrated Management of Pest Insects & Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China) ,  Thevissen Karin (Centre of Microbial and Plant Genetics, KU Leuven, Kasteelpark Arenberg 20, PO Box 2460, 3001 Leuven, Belgium) ,  Cammue Bruno P.A. (Centre of Microbial and Plant Genetics, KU Leuven, Kasteelpark Arenberg 20, PO Box 2460, 3001 Leuven, Belgium) ,  Cammue Bruno P.A. (VIB Department of Plant Systems Biology, Technologiepark 927, 9052 Ghent, Belgium) ,  Sato Kazuki (Department of Environmental Science, Fukuoka Women’s University, Fukuoka 813-8529, Japan) ,  Tytgat Jan (Toxicology and Pharmacology, KU Leuven, Campus Gasthuisberg O&N2, Herestraat 49, PO Box 922, 3000 Leuven, Belgium)
Material： Peptides (N.Y.)
Volume： 98  Page： 43-50  Publication year： 2017 
JST Material Number： W0486A  ISSN： 0196-9781  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Peptide toxins, such as scorpi...

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Thesaurus term： structure-activity relationship ,  antifungal action ,  potassium channel ,  toxin ,  *analogical material ,  Eumycetes ,  *carcinogenicity ,  antitumor drug ,  affinity ,  peptide ,  screening(inspection) ,  *channel ,  amino acid residue
Semi thesaurus term： 残基 ,  阻害剤 , 【Automatic Indexing@JST】

Author keywords (6)： κ-Hefutoxin 1 ,  Scorpion ,  K_v10.1 ,  Potassium channel ,  Cancer ,  Antifungal assays

JST classification (2)： Bioactive peptides  (EB08100U) ,  Biological function  (EB03040U)

Terms in the title (8)： 類似体 ,  薬理学 ,  プロフィル ,  拡大 ,  発癌性 ,  チャネル ,  阻害効果 ,  焦点