Art

J-GLOBAL ID：201802274946799027   Reference number：18A1298493

Conserved Residues Lys⁵⁷ and Lys⁴⁰¹ of Protein Disulfide Isomerase Maintain an Active Site Conformation for Optimal Activity: Implications for Post-Translational Regulation

蛋白質ジスルフィドイソメラーゼの保存残基Lys57とLys401は最適活性のための活性部位立体配座を維持する:翻訳後調節に対する意味【JST・京大機械翻訳】

Author (7)： Caba Cody (Department of Chemistry and Biochemistry, University of Windsor) ,  Ali Khan Hyder (Department of Chemistry and Biochemistry, University of Windsor) ,  Auld Janeen (Department of Chemistry and Biochemistry, University of Windsor) ,  Ushioda Ryo (Laboratory of Molecular and Cellular Biochemistry, Faculty of Life Sciences, Kyoto Sangyo University) ,  Araki Kazutaka (Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology) ,  Nagata Kazuhiro (Laboratory of Molecular and Cellular Biochemistry, Faculty of Life Sciences, Kyoto Sangyo University) ,  Mutus Bulent (Department of Chemistry and Biochemistry, University of Windsor)
Material： Frontiers in Molecular Biosciences (Web)
Volume： 5  Page： 18  Publication year： 2018 
JST Material Number： U7081A  ISSN： 2296-889X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Despite its study since the 19...

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Thesaurus term： Acetylation ,  *post-translational modification ,  rate theory ,  human ,  oxidation-reduction reaction ,  *active site ,  *steric conformation ,  in vitro experiment ,  mutagenesis ,  catalyst ,  *Proteins ,  Lys residue ,  Amino Acid Substitution ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  primary amine
Semi thesaurus term： *残基 , 【Automatic Indexing@JST】

Author keywords (6)： lysine acetylation ,  oxidative protein folding ,  enzyme kinetics ,  protein disulfide isomerase ,  redox ,  thiol-disulfide exchange

JST classification (3)： Molecular structure  (EB03020Y) ,  Biological function  (EB03040U) ,  Gene expression  (EC02040Q)

Substance index (1)： Lysine

Terms in the title (8)： 蛋白質ジスルフィドイソメラーゼ ,  保存 ,  残基 ,  活性 ,  活性部位 ,  立体配座 ,  翻訳後調節 ,  意味