Art

J-GLOBAL ID：201802275057671453   Reference number：18A0855291

Synthesis and inhibitory activity of mechanism-based 4-coumaroyl-CoA ligase inhibitors

機構に基づく4-coumaroyl-CoAリガーゼ阻害剤の合成と阻害活性【JST・京大機械翻訳】

Author (12)： Watanabe Bunta (Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan) ,  Kirikae Hiroaki (Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan) ,  Koeduka Takao (Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan) ,  Takeuchi Yoshinori (Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan) ,  Asai Tomoki (Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan) ,  Naito Yoshiyuki (Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan) ,  Tokuoka Hideya (Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan) ,  Horoiwa Shinri (Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan) ,  Nakagawa Yoshiaki (Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan) ,  Shimizu Bun-ichi (Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan) ,  Mizutani Masaharu (Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan) ,  Hiratake Jun (Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 26  Issue： 9  Page： 2466-2474  Publication year： 2018 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： 4-Coumaroyl-CoA ligase (4CL) i...

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Thesaurus term： substrate specificity ,  Populus ,  chemical substance ,  *ligase ,  flavonoid ,  lignin ,  NMR ,  structure-activity relationship ,  human(primates) ,  biosynthesis ,  plant growth ,  lactone ,  polynuclear aromatic compound
Semi thesaurus term： フェニルプロパノイド ,  *阻害活性 ,  *阻害剤 , 【Automatic Indexing@JST】

Author keywords (4)： 4-Coumaroyl-CoA ligase ,  Mechanism-based inhibitor ,  ANL superfamily ,  Acylsulfamide

JST classification (2)： Enzyme in general  (EB09010D) ,  Condensed derivatives of pyrane  (CF07093I)

Substance index (1)： Coumarin

Terms in the title (3)： リガーゼ ,  阻害剤 ,  阻害活性