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J-GLOBAL ID：201802276179440588   Reference number：18A0129678

Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer’s disease

アルファ7ニコチン性アセチルコリン受容体特異的作動薬DMXBA(GTS 21)はニューロンγ-セクレターゼ活性の抑制とミクログリアのアミロイドβどん食作用の促進を介してAβ蓄積を低下させ,Alzheimer病のマウスモデルにおける認知障害を改善する【Powered by NICT】

Author (19)： Takata Kazuyuki (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Amamiya Takahide (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Mizoguchi Hiroaki (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Kawanishi Shohei (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Kuroda Eriko (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Kitamura Risa (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Ito Aina (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Saito Yuki (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Tawa Manami (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Nagasawa Tomofumi (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Okamoto Haruka (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Sugino Yuko (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Takegami Shigehiko (Department of Analytical Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Kitade Tatsuya (Department of Analytical Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Toda Yuki (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Kem William R. (Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL, USA) ,  Kitamura Yoshihisa (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan) ,  Shimohama Shun (Department of Neurology, Sapporo Medical University, School of Medicine, Sapporo, Japan) ,  Ashihara Eishi (Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
Material： Neurobiology of Aging  (Neurobiol Aging)
Volume： 62  Page： 197-209  Publication year： 2018 
JST Material Number： W0356A  ISSN： 0197-4580  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We previously demonstrated tha...

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Thesaurus term： primary culture ,  memory disorder ,  *Alzheimer disease ,  human(primates) ,  *amyloid beta-protein ,  *neuron ,  *phagocytosis ,  transgenic mouse ,  *microglia ,  *nicotinic receptor
Semi thesaurus term： *セクレターゼ ,  *認知障害 ,  *マウスモデル ,  *γセクレターゼ ,  *アゴニスト , 【Automatic Indexing@JST】

Author keywords (6)： α7 Nicotinic acetylcholine receptor ,  Amyloid-β ,  Microglia ,  Phagocytosis ,  Neuron ,  γ-Secretase

JST classification (1)： Basic neurology  (GN01020W)

Terms in the title (13)： アルファ7ニコチン性アセチルコリン受容体 ,  作動薬 ,  ニューロン ,  γ-セクレターゼ ,  活性 ,  ミクログリア ,  アミロイドβ ,  どん食作用 ,  促進 ,  蓄積 ,  Alzheimer病 ,  マウスモデル ,  認知障害