Art

J-GLOBAL ID：201802276227984220   Reference number：18A1010914

Diabetes Mellitus Induces Hyperreactivity of 5-Hydroxytryptamine (5-HT)-Induced Constriction in Human Internal Thoracic Artery and Is Associated with Increase in the Membrane Protein Level of 5-HT_2A Receptor

糖尿病はヒト内胸動脈における5-ヒドロキシトリプタミン(5-HT)誘発性収縮の反応性亢進を誘発し,5-HT_2A受容体の膜タンパク質レベルの増加と関連している

Author (10)： Shiba Tatsuo (First Department of Pharmacology, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare) ,  Yokota Atsuko (Department of Cardiovascular Surgery, Miyazaki Prefectural Nobeoka Hospital) ,  Yokota Atsuko (Department of Surgery, Faculty of Medicine, Miyazaki University) ,  Gamoh Shuji (First Department of Pharmacology, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare) ,  Tanaka-Totoribe Naoko (First Department of Pharmacology, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare) ,  Kuwabara Masachika (Kuwabara Clinic) ,  Nakamura Eisaku (Department of Surgery, Faculty of Medicine, Miyazaki University) ,  Hayase Takahiro (Department of Cardiovascular Surgery, Miyazaki Prefectural Nobeoka Hospital) ,  Nakamura Kunihide (Department of Surgery, Faculty of Medicine, Miyazaki University) ,  Yamamoto Ryuichi (First Department of Pharmacology, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 5  Page： 820-823(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： Receptor, Serotonin, 5-HT2A ,...

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Author keywords (10)： 5-hydroxytryptamine ,  coronary artery bypass grafting ,  diabetes mellitus ,  internal thoracic artery ,  vasospasm ,  5-hydroxytryptamine ,  coronary artery bypass grafting ,  diabetes mellitus ,  internal thoracic artery ,  vasospasm

JST classification (2)： Surgical treatment for cardiovascular system diseases  (GJ05030X) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (1)： Serotonin

Reference (13)：

• 1) Carson JL, Scholz PM, Chen AY, Peterson ED, Gold J, Schneider SH. Diabetes mellitus increases short-term mortality and morbidity in patients undergoing coronary artery bypass graft surgery. J. Am. Coll. Cardiol., 40, 418-423 (2002).
• 2) Chanda J, Canver CC. Reversal of preexisting vasospasm in coronary-artery conduits. Ann. Thorac. Surg., 72, 476-480 (2001).
• 3) Fabricius AM, Gerber W, Hanke M, Garbade J, Autschbach R, Mohr FW. Early angiographic control of perioperative ischemia after coronary artery bypass grafting. Eur. J. Cardiothorac. Surg., 19, 853-858 (2001).
• 4) Gamoh S, Hisa H, Yamamoto R. 5-Hydroxytrypamine receptors as targets for drug therapies of vascular-related diseases. Biol. Pharm. Bull., 36, 1410-1415 (2013).
• 5) Eriksson L, Nyström T. Antidiabetic agents and endothelial dysfunction-beyond glucose control. Basic Clin. Pharmacol. Toxicol., 117, 15-25 (2015).

Terms in the title (11)： 糖尿病 ,  ヒト ,  内胸動脈 ,  5-ヒドロキシトリプタミン ,  5-HT ,  収縮 ,  反応性 ,  亢進 ,  誘発 ,  5-HT2A受容体 ,  膜タンパク質