Art

J-GLOBAL ID：201802276613636599   Reference number：18A0418565

Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice

マウスにおける確立されたアレルギー性結膜炎の治療のための低アレルゲン性ニホンスギ花粉アレルゲンを含むコメに基づく可食ワクチンでの経口免疫療法の効果

Author (7)： Fukuda Ken (Department of Ophthalmology and Visual Science, Kochi Medical School) ,  Ishida Waka (Department of Ophthalmology and Visual Science, Kochi Medical School) ,  Harada Yosuke (Department of Ophthalmology and Visual Science, Kochi Medical School) ,  Wakasa Yuhya (Plant Molecular Farming Unit, Division of Biotechnology, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization) ,  Takagi Hidenori (Plant Molecular Farming Unit, Division of Biotechnology, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization) ,  Takaiwa Fumio (Plant Molecular Farming Unit, Division of Biotechnology, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization) ,  Fukushima Atsuki (Department of Ophthalmology and Visual Science, Kochi Medical School)
Material： Allergology International  (Allergol Int)
Volume： 67  Issue： 1  Page： 119-123(J-STAGE)  Publication year： 2018 
JST Material Number： L6446A  ISSN： 1323-8930  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： *Conjunctivitis, Allergic ,...

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Author keywords (10)： Allergic conjunctivitis ,  Immunotherapy ,  Oral tolerance ,  Pollen ,  Transgenic rice ,  Allergic conjunctivitis ,  Immunotherapy ,  Oral tolerance ,  Pollen ,  Transgenic rice

JST classification (1)： Basic ophthalmology  (GP01020C)

Reference (21)：

• 1. Okamoto Y, Horiguchi S, Yamamoto H, Yonekura S, Hanazawa T. Present situation of cedar pollinosis in Japan and its immune responses. Allergol Int 2009;58:155-62.
• 2. Senna G, Lombardi C, Canonica GW, Passalacqua G. How adherent to sublingual immunotherapy prescriptions are patients? The manufacturers' viewpoint. J Allergy Clin Immunol 2010;126:668-9.
• 3. Takaiwa F. Seed-based oral vaccines as allergen-specific immunotherapies. Hum Vaccin 2011;7:357-66.
• 4. Wakasa Y, Takagi H, Hirose S, Yang L, Saeki M, Nishimura T, et al. Oral immunotherapy with transgenic rice seed containing destructed Japanese cedar pollen allergens, Cry j 1 and Cry j 2, against Japanese cedar pollinosis. Plant Biotechnol J 2013;11:66-76.
• 5. Fukuda K, Ishida W, Harada Y, Wakasa Y, Takagi H, Takaiwa F, et al. Prevention of allergic conjunctivitis in mice by a rice-based edible vaccine containing modified Japanese cedar pollen allergens. Br J Ophthalmol 2015;99:705-9.

Terms in the title (9)： マウス ,  アレルギー性結膜炎 ,  治療 ,  アレルゲン性 ,  ニホン ,  スギ ,  コメ ,  ワクチン ,  経口免疫療法