Art

J-GLOBAL ID：201802276631704954   Reference number：18A1197264

Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes

CD4誘導エピトープを標的とする単鎖可変断片(scFv)の広範な中和活性に対するユニークな結合モード【JST・京大機械翻訳】

Author (9)： Tanaka Kazuki (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University, Kumamoto, Japan) ,  Kuwata Takeo (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University, Kumamoto, Japan) ,  Alam Muntasir (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University, Kumamoto, Japan) ,  Kaplan Gilad (Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel) ,  Takahama Shokichi (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University, Kumamoto, Japan) ,  Valdez Kristel Paola Ramirez (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University, Kumamoto, Japan) ,  Roitburd-Berman Anna (Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel) ,  Gershoni Jonathan M. (Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel) ,  Matsushita Shuzo (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University, Kumamoto, Japan)
Material： Retrovirology (Web)
Volume： 14  Issue： 1  Page： 44  Publication year： 2017 
JST Material Number： U7344A  ISSN： 1742-4690  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background The CD4-induced (CD...

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Thesaurus term： HIV1 ,  *epitope ,  neutralizing antibody ,  infection ,  binding site ,  monoclonal antibody ,  conformational transition ,  targeting ,  interaction ,  *neutralization ,  immunoglobulin G ,  therapy ,  reactivity ,  *CD4 antigen
Semi thesaurus term： *scFv , 【Automatic Indexing@JST】

Author keywords (4)： HIV-1 neutralizing antibody ,  scFv ,  CD4i epitopes ,  Bridging sheet

JST classification (2)： Virus biochemistry  (EG04030F) ,  Biochemistry of antigens,antibodies,complements  (ED04020L)

Reference (60)：

• Science; Epitopes of the CD4 antigen and HIV infection; QJ Sattentau, AG Dalgleish, RA Weiss, PC Beverley; 234; 1986; 1120-1123; 10.1126/science.2430333; CR1;
• J Exp Med; Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding; QJ Sattentau, JP Moore; 174; 1991; 407-415; 10.1084/jem.174.2.407; CR2;
• Nature; Molecular architecture of native HIV-1 gp120 trimers; J Liu, A Bartesaghi, MJ Borgnia, G Sapiro, S Subramaniam; 455; 2008; 109-113; 10.1038/nature07159; CR3;
• Nat Commun; Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env; M Guttman, A Cupo, J Julien, RW Sanders, IA Wilson, JP Moore, KK Lee; 6; 2015; 6144; 10.1038/ncomms7144; CR4;
• Proc Natl Acad Sci USA; Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop; H Wang, AA Cohen, RP Galimidi, HB Gristick, GJ Jensen, PJ Bjorkman; 113; 2016; 7151-7158; 10.1073/pnas.1615939113; CR5;

Terms in the title (10)： CD4 ,  誘導 ,  エピトープ ,  標的 ,  可変 ,  断片 ,  scFv ,  中和 ,  活性 ,  結合モード