Art

J-GLOBAL ID：201802276948806914   Reference number：18A0031509

ONE-POT, DIVERSITY-ORIENTED SYNTHESIS OF ARYL-SUBSTITUTED BENZOXACYCLES INCLUDING BENZOFURAN, COUMARIN, AND BENZOXAZEPINE

ベンゾフラン,クマリン,およびベンゾオキサゼピンを含むアリール置換ベンゾオキサ環のワンポット,多様性指向合成

Author (5)： MASUI Hisashi (Yokohama Univ. Pharmacy, Yokohama, JPN) ,  OHKAWA Eri (Yokohama Univ. Pharmacy, Yokohama, JPN) ,  KITAHARA Rika (Yokohama Univ. Pharmacy, Yokohama, JPN) ,  WANIBUCHI Kiyofumi (Yokohama Univ. Pharmacy, Yokohama, JPN) ,  TAKAHASHI Takashi (Yokohama Univ. Pharmacy, Yokohama, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 94  Issue： 12  Page： 2273-2290  Publication year： Dec. 01, 2017 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *oxygen heterocyclic compound ,  *polynuclear aromatic compound ,  *lactone ,  nitrogen heterocyclic compound ,  one-pot synthesis ,  chemical synthesis ,  potassium carbonate ,  sodium compound ,  hydride ,  molecular structure ,  addition reaction ,  *cyclization reaction ,  alicyclic hydrocarbon ,  aromatic ketone ,  phenolic compound ,  phenol ether ,  hydroxy ketone
Semi thesaurus term： Oxazepines ,  Oxazocines ,  *Coumarins ,  *Benzofurans ,  sodium hydride ,  diversity-oriented synthesis

JST classification (2)： Condensed derivatives of furan  (CF07073M) ,  Cyclization reaction,ring-opening reaction  (CF02050I)

Substance index (22)： trans-Decalin ,  2-Hydroxy-4-methoxybenzophenone ,  Bromo-(4-benzyloxyphenyl)acetic acid methyl ester ,  2-(4-Benzyloxyphenyl)-3-phenyl-6-methoxybenzofuran- ,  3-Acetyl-4-phenyl-7-methoxy-2H-1-benzopyran-2-one ,  2,3-Dihydro-5-phenyl-8-methoxy-1,4-benzooxazepine ,  3-Phenyl-7-methoxybenzofuran-2-carboxylic acid methyl ester ,  1-Tosyl-2-(2-hydroxy-4-methoxybenzoyl)-3-(2,2-dimethyl-3-Boc-oxazolidine-4-ylmethyl)1H-indole ,  1-Tosyl-2-(2-(4-(benzyloxy)phenyl)-6-methoxybenzofuran-3-yl)-3-(2,2-dimethyl-3-Boc-oxazolidine-4-ylmethyl)-1H-indole ,  3-Butanoyl-4-phenyl-7-methoxy-2H-1-benzopyran-2-one ,  1-(2-Hydroxyphenyl)-2,6-dimethylheptane-1-one ,  2,3-Dihydro-5-(1,5-dimethylhexyl)-1,4-benzooxazepine ,  6-Phenyl-9-methoxy-3,4-dihydro-2H-1,5-benzooxazocine ,  4-Hydroxymandelic acid ,  α,4-Dihydroxybenzeneacetic acid methyl ester ,  Hydroxy(4-(benzyloxy)phenyl)acetic acid methyl ester ,  3-(2,2-Dimethyl-3-Boc-oxazolidine-4-ylmethyl)-1H-indole ,  2-(2-(Benzyloxy)-4-methoxybenzoyl)-3-(2,2-dimethyl-3-Boc-oxazolidine-4-ylmethyl)-1H-indole ,  2-(4-Methoxyphenyl)benzofuran ,  1,7β-Bis(4-hydroxyphenyl)-6,7-dihydro-2-oxa-2H-dibenz[cd,h]azulene-4,6β,8,10-tetrol ,  4-(3-Hydroxy-4-methoxyphenyl)-5,7-dimethoxycoumarin ,  N-(7-Chloro-1α,14bβ,3,4-tetrahydro-2H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepine-1β-yl)trifluoroacetamide

Reference (28)：

• A. Martins, U. Marquardt, N. Kasravi, D. Alberico, and M. Lautens, J. Org. Chem., 2006, 71, 4937; J. Li, C. Tan, X. Mu, J. Gong, and Z. Yang, Chin. J. Chem., 2017, 35, 562.
• X. Jiang, W. Liu, W. Zhang, F. Jiang, Z. Gao, H. Zhuang, and L. Fu, Eur. J. Med. Chem., 2011, 46, 3526.
• W. Yang, X. Chen, J. Pan, H. Ge, K. Yin, Z. Wu, X. Li, D. Sha, and Y. Xu, Neurochem. Int., 2015, 80, 33.
• C. Bailly, C. Bal, P. Barbier, S. Combes, J.-P. Finet, M.-P. Hildebrand, V. Peyrot, and N. Wattez, J. Med. Chem., 2003, 46, 5437.
• P. P. M. A. Dols, B. J. B. Folmer, H. Hamersma, C. W. Kuil, H. Lucas, L. Ollero, J. B. M. Rewinkel, and P. H. H. Hermkens, Bioorg. Med. Chem. Lett., 2008, 18, 1461.

Terms in the title (6)： ベンゾフラン ,  クマリン ,  アリール置換 ,  環 ,  ポット ,  多様性指向合成