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J-GLOBAL ID：201802277383878988   Reference number：18A2083608

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain

Alzheimer病脳において可溶性Aβの重要な少数を表す拡散性の高生物活性オリゴマー【JST・京大機械翻訳】

Author (11)： Hong Wei (Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Wang Zemin (Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Liu Wen (Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  O'Malley Tiernan T. (Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Jin Ming (Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Willem Michael (Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany) ,  Haass Christian (Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany) ,  Haass Christian (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ,  Haass Christian (German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany) ,  Frosch Matthew P. (Massachusetts General Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA) ,  Walsh Dominic M. (Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA)
Material： Acta Neuropathologica
Volume： 136  Issue： 1  Page： 19-40  Publication year： 2018 
JST Material Number： A0895B  ISSN： 0001-6322  CODEN： ANPTA  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Significant data suggest that ...

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Thesaurus term： *solubility(property) ,  *biological activity ,  targeting ,  antibody ,  therapy ,  *Alzheimer disease ,  aggregation ,  uncertainty ,  homogenization ,  *oligomer ,  neuron ,  amyloid beta-protein ,  human(primates) ,  plaque
Semi thesaurus term： アミロイドβペプチド , 【Automatic Indexing@JST】

Author keywords (6)： Amyloid β-protein ,  Automated live-cell imaging ,  iPSC-derived human neurons ,  Long-term potentiation ,  Neuritic dystrophy ,  Soluble aggregates

JST classification (1)： Basic neurology  (GN01020W)

Terms in the title (6)： Alzheimer病 ,  脳 ,  可溶性 ,  拡散性 ,  生物活性 ,  オリゴマー