Art

J-GLOBAL ID：201802277673756024   Reference number：18A0067177

Applicability of an Integrated Testing Strategy consisting of in silico, in chemico and in vitro assays for evaluating the skin sensitization potencies of isocyanates

イソシアネートの皮膚感作効力を評価するためのin silico,in chemicoとin vitroアッセイの統合試験戦略の適用性【Powered by NICT】

Author (6)： Ohtake Toshiyuki (Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute (CERI), 1600, Shimotakano, Sugito-machi, Kitakatsushika-gun, Saitama 345-0043, Japan) ,  Maeda Yosuke (Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute (CERI), 1600, Shimotakano, Sugito-machi, Kitakatsushika-gun, Saitama 345-0043, Japan) ,  Hayashi Tae (Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute (CERI), 1-4-25 Koraku, Bunkyo-ku, Tokyo 112-0004, Japan) ,  Yamanaka Hidenori (Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute (CERI), 1600, Shimotakano, Sugito-machi, Kitakatsushika-gun, Saitama 345-0043, Japan) ,  Nakai Makoto (Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute (CERI), 1600, Shimotakano, Sugito-machi, Kitakatsushika-gun, Saitama 345-0043, Japan) ,  Takeyoshi Masahiro (Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute (CERI), 1-4-25 Koraku, Bunkyo-ku, Tokyo 112-0004, Japan)
Material： Toxicology
Volume： 393  Page： 9-14  Publication year： 2018 
JST Material Number： D0444C  ISSN： 0300-483X  CODEN： TXCYAC  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The skin sensitization potenti...

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Thesaurus term： *sensitization(immunology) ,  chemical substance ,  reactivity ,  solubility(ratio) ,  lymph node ,  *in vitro experiment ,  safety evaluation ,  allergen ,  animal test ,  forecast ,  *adaptability ,  isocyanate
Semi thesaurus term： *in silico ,  LLNA ,  *皮膚感作 , 【Automatic Indexing@JST】

Author keywords (4)： Isocyanates ,  Skin sensitization ,  LLNA ,  ITS

JST classification (2)： Toxicity of chemical substances in general  (GZ02010C) ,  Bioassay  (EA03060N)

Terms in the title (8)： イソシアネート ,  皮膚感作 ,  評価 ,  アッセイ ,  統合 ,  試験 ,  戦略 ,  適用性