Art

J-GLOBAL ID：201802278121243764   Reference number：18A0336877

Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.

2インドネシアの海洋海綿動物,IrciniaとSpongia種から得られた新しいタイプの蛋白質チロシンホスファターゼ1B阻害剤の,フラノテルペン。【Powered by NICT】

Author (10)： Abdjul Delfly B. (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan) ,  Abdjul Delfly B. (Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia) ,  Yamazaki Hiroyuki (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan) ,  Kanno Syu-ichi (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan) ,  Wewengkang Defny S. (Faculty of Mathematic and Natural Sciences, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia) ,  Rotinsulu Henki (Faculty of Mathematic and Natural Sciences, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia) ,  Sumilat Deiske A. (Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia) ,  Ukai Kazuyo (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan) ,  Kapojos Magie M. (Faculty of Nursing, University of Pembangunan Indonesia, Bahu, Manado 95115, Indonesia) ,  Namikoshi Michio (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 27  Issue： 5  Page： 1159-1161  Publication year： 2017 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Protein tyrosine phosphatase (...

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Thesaurus term： *phosphatase ,  Type 2 diabetes mellitus ,  *protein tyrosine phosphatase ,  hepatoma ,  cytotoxicity ,  human ,  insulin ,  T cell ,  *Porifera ,  phosphorylation ,  inhibitory activity ,  *protein tyrosine phosphatase-1B ,  *Spongia ,  hypoglycemic drug ,  metabolic drug ,  carbohydrate metabolic drug ,  drug ,  *invertebrate
Semi thesaurus term： *阻害剤 ,  *Spongia ,  *Ircinia , 【Automatic Indexing@JST】

Author keywords (5)： Furanosesterterpene ,  C21 furanoterpene ,  Marine sponge ,  Protein tyrosine phosphatase 1B ,  Inhibitor

JST classification (2)： Enzyme in general  (EB09010D) ,  Structure-activity relationship of drugs  (GV01050B)

Terms in the title (8)： インドネシア ,  海洋 ,  海綿動物 ,  Spongia ,  タイプ ,  蛋白質チロシンホスファターゼ1B ,  阻害剤 ,  テルペン