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J-GLOBAL ID：201802278723860181   Reference number：18A1610933

Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures

エピベルベリンによるハイブリッド-2ヒトテロメアG-四重鎖の分子認識:テロメアG-四重鎖構造の変換への洞察【JST・京大機械翻訳】

Author (8)： Lin Clement (Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA) ,  Wu Guanhui (Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA) ,  Wang Kaibo (Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA) ,  Onel Buket (Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA) ,  Sakai Saburo (Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA) ,  Sakai Saburo (Institute of Biogeochemistry, Japan Agency for Marine-Earth Science and Technology, Yokosuka, Kanagawa, 237-0061, Japan) ,  Shao Yong (College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, 321004, China) ,  Yang Danzhou (Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 57  Issue： 34  Page： 10888-10893  Publication year： 2018 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Human telomeres can form DNA G...

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Thesaurus term： *heavy chain ,  small molecule ,  protein ,  complex(substance) ,  *human(primates) ,  NMR ,  binding site ,  natural material ,  DNA ,  *telomere ,  antitumor drug ,  telomerase ,  *molecular recognition ,  oxygen heterocyclic compound ,  pyridinium ,  protoberberine alkaloid ,  phenol ether ,  polynuclear aromatic compound
Semi thesaurus term： *G-四重鎖 , 【Automatic Indexing@JST】

Author keywords (6)： anticancer drug targets ,  G4-drug complexes ,  human telomeres ,  G-quadruplexes ,  NMR spectroscopy ,  berberine

JST classification (1)： Nucleic acids in general  (EB04010U)

Substance index (1)： Berberine

Terms in the title (6)： エピベルベリン ,  ヒト ,  テロメア ,  G-四重鎖 ,  分子認識 ,  洞察