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J-GLOBAL ID：201802280002357292   Reference number：18A1296469

Empirical Bayes Estimation of Semi-parametric Hierarchical Mixture Models for Unbiased Characterization of Polygenic Disease Architectures

多遺伝子疾患アーキテクチャの不偏特性化のための半パラメトリック階層混合モデルの経験的Bayes推定【JST・京大機械翻訳】

Author (28)： Nishino Jo (Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)) ,  Nishino Jo (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Kochi Yuta (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Kochi Yuta (Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences) ,  Shigemizu Daichi (Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)) ,  Shigemizu Daichi (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Shigemizu Daichi (Division of Genomic Medicine, Medical Genome Center, National Center for Geriatrics and Gerontology) ,  Shigemizu Daichi (Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences) ,  Kato Mamoru (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Kato Mamoru (Department of Bioinformatics, National Cancer Center Research Institute) ,  Ikari Katsunori (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Ikari Katsunori (Institute of Rheumatology, Tokyo Women’s Medical University) ,  Ochi Hidenori (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Ochi Hidenori (Division of Frontier Medical Science, Department of Gastroenterology and Metabolism, Programs for Biomedical Research Graduate School of Biomedical Science, Hiroshima University) ,  Ochi Hidenori (Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences) ,  Noma Hisashi (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Noma Hisashi (Department of Data Science, The Institute of Statistical Mathematics) ,  Matsui Kota (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Matsui Kota (Department of Biostatistics, Nagoya University Graduate School of Medicine) ,  Morizono Takashi (Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences) ,  Boroevich Keith A. (Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences) ,  Tsunoda Tatsuhiko (Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)) ,  Tsunoda Tatsuhiko (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Tsunoda Tatsuhiko (Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences) ,  Tsunoda Tatsuhiko (Risk Analysis Research Center, The Institute of Statistical Mathematics) ,  Matsui Shigeyuki (Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST)) ,  Matsui Shigeyuki (Department of Biostatistics, Nagoya University Graduate School of Medicine) ,  Matsui Shigeyuki (Risk Analysis Research Center, The Institute of Statistical Mathematics)
Material： Frontiers in Genetics (Web)
Volume： 9  Page： 115  Publication year： 2018 
JST Material Number： U7071A  ISSN： 1664-8021  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Genome-wide association studie...

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Thesaurus term： allele ,  rheumatoid arthritis ,  schizophrenia ,  unbiased estimation ,  pathogenesis ,  gene frequency ,  Genome-Wide Association Study ,  *gene ,  stratification ,  *Bayes estimation ,  mutation ,  *characterization ,  *heredity ,  genome
Semi thesaurus term： オッズ比 , 【Automatic Indexing@JST】

Author keywords (5)： genome-wide association study (GWAS) ,  polygenic disease architecture ,  polygenicity ,  effect-size distribution ,  semi-parametric hierarchical mixture model

JST classification (2)： Genetic variation  (EC01030Y) ,  Research methods in genetics  (EC01020N)

Terms in the title (8)： 遺伝子 ,  疾患 ,  アーキテクチャ ,  特性化 ,  階層 ,  混合モデル ,  経験 ,  Bayes推定