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J-GLOBAL ID：201802280955074437   Reference number：18A1111551

Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma

PD-1を標的とする自己送達RNAiは悪性黒色腫の養子細胞療法のための腫瘍特異的T細胞機能性を改善する【JST・京大機械翻訳】

Author (14)： Ligtenberg Maarten A. (Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm 17176, Sweden) ,  Pico de Coana Yago (Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm 17176, Sweden) ,  Shmushkovich Taisia (Advirna LLC, Worcester, MA 01605, USA) ,  Yoshimoto Yuya (Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm 17176, Sweden) ,  Yoshimoto Yuya (Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi 371-8510, Japan) ,  Truxova Iva (Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm 17176, Sweden) ,  Truxova Iva (Charles University, 2nd Faculty of Medicine and University Hospital Motol, 150 06 Prague, Czech Republic) ,  Truxova Iva (Sotio A.S., 170 00 Prague, Czech Republic) ,  Yang Yuan (Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm 17176, Sweden) ,  Yang Yuan (Clinical Research Center, Guizhou Medical University Hospital, Guiyang 550025, People’s Republic of China) ,  Betancur-Boissel Monica (Advirna LLC, Worcester, MA 01605, USA) ,  Eliseev Alexey V. (RXi Pharmaceuticals, Marlborough, MA 01752, USA) ,  Wolfson Alexey D. (Advirna LLC, Worcester, MA 01605, USA) ,  Kiessling Rolf (Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm 17176, Sweden)
Material： Molecular Therapy  (Mol Ther)
Volume： 26  Issue： 6  Page： 1482-1493  Publication year： 2018 
JST Material Number： W1762A  ISSN： 1525-0016  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Adoptive cell therapy (ACT) is...

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Thesaurus term： siRNA ,  interferon gamma ,  gene expression ,  patient ,  *adoptive immunotherapy ,  antigen ,  *RNA ,  non-small cell lung cancer ,  combination therapy ,  antibody ,  *T cell ,  Proteins ,  *RNA interference ,  protocol ,  *malignant melanoma ,  molecular genetic phenomenon ,  *Heredity

Author keywords (7)： PD-1 ,  checkpoint blockade ,  adoptive cell therapy ,  rapid expansion protocol ,  RNA interference ,  sdRNA ,  sd-rxRNA

JST classification (2)： Tumor immunity  (ED03040A) ,  Immunotherapy for tumors  (GE03035B)

Terms in the title (10)： PD-1 ,  標的 ,  自己 ,  送達 ,  RNAi ,  悪性黒色腫 ,  養子細胞療法 ,  腫瘍 ,  T細胞 ,  機能性