Art
J-GLOBAL ID：201802281845411467   Reference number：18A0124737

Trametinib suppresses HIV-1 replication by interfering with the disassembly of human immunodeficiency virus type 1 capsid core

トラメチニブはヒト免疫不全ウイルス1型カプシドコアの分解を阻害することによりHIV-1複製を抑制する【Powered by NICT】
Author (5)：
Dochi Takeo

About Dochi Takeo

(Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan)

About Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan

, 
Akita Ayano

About Akita Ayano

(Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan)

About Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan

, 
Kishimoto Naoki

About Kishimoto Naoki

(Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan)

About Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan

, 
Takamune Nobutoki

About Takamune Nobutoki

(Innovative Collaboration Organization, Kumamoto University, Kumamoto 860-8555, Japan)

About Innovative Collaboration Organization, Kumamoto University, Kumamoto 860-8555, Japan

, 
Misumi Shogo

About Misumi Shogo

(Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan)

About Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan


Material：
Biochemical and Biophysical Research Communications  (BBRC)

About Biochemical and Biophysical Research Communications


Volume： 495  Issue： 2  Page： 1846-1850  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
virion

About virion

, 
infection

About infection

, 
*capsid

About capsid

, 
protein

About protein

, 
MAP kinase kinase

About MAP kinase kinase

, 
reverse transcription

About reverse transcription

, 
*human(primates)

About human(primates)

, 
crust

About crust

, 
phosphorylation

About phosphorylation

, 
*HIV1

About HIV1

, 
T cell

About T cell


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
感染性

About 感染性

, 
MEK1/2

About MEK1/2

, 
*HIV1複製

About HIV1複製

, 【Automatic Indexing@JST】
Author keywords (5)：
Trametinib

About Trametinib

, 
ERK2

About ERK2

, 
Uncoating

About Uncoating

, 
MEK1/2

About MEK1/2

, 
Human immunodeficiency virus type 1

About Human immunodeficiency virus type 1

JST classification (3)：
JST classification
Category name(code) classified by JST.
Physiology and pathogenicity of virus infection 
(EG04042Y)

About Physiology and pathogenicity of virus infection

,  Virus biochemistry 
(EG04030F)

About Virus biochemistry

,  Basic research of antiviral drugs 
(GW17040O)

About Basic research of antiviral drugs

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
Trametinib

About Trametinib

Terms in the title (7)：
Terms in the title
Keywords automatically extracted from the title.
トラメチニブ

About トラメチニブ

, 
ヒト免疫不全ウイルス1型

About ヒト免疫不全ウイルス1型

, 
カプシド

About カプシド

, 
コア

About コア

, 
分解

About 分解

, 
阻害

About 阻害

, 
HIV-1複製

About HIV-1複製


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