Art

J-GLOBAL ID：201802282544197812   Reference number：18A1691338

Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties

クローン病患者由来小腸オルガノイドのシングルセル解析は幹細胞性状の疾患活動性に依存する変化を明らかにする

Author (22)： SUZUKI Kohei (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  MURANO Tatsuro (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  SHIMIZU Hiromichi (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  ITO Go (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  NAKATA Toru (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  FUJII Satoru (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  ISHIBASHI Fumiaki (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  KAWAMOTO Ami (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  ANZAI Sho (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  KUNO Reiko (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  KUWABARA Konomi (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  TAKAHASHI Junichi (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  HAMA Minami (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  NAGATA Sayaka (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  HIRAGURI Yui (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  TAKENAKA Kento (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  YUI Shiro (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  TSUCHIYA Kiichiro (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  NAKAMURA Tetsuya (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  OHTSUKA Kazuo (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  WATANABE Mamoru (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  OKAMOTO Ryuichi (Tokyo Medical and Dental Univ., Tokyo, JPN)
Material： Journal of Gastroenterology  (J Gastroenterol)
Volume： 53  Issue： 9  Page： 1035-1047  Publication year： 2018 
JST Material Number： Z0748A  ISSN： 0944-1174  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： SLC12A2遺伝子 ,...

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JST classification (1)： Clinical medicine on digestive system in general  (GH01030P)

Reference (41)：

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• Okamoto R, Watanabe M. Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease. J Gastroenterol. 2016;51:11-21.
• Clevers H. The intestinal crypt, a prototype stem cell compartment. Cell. 2013;154:274-84.
• Muñoz JMN, Stange DE, Schepers AG, et al. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent “+4” cell markers. EMBO J. 2012;31:3079-91.
• Foulke-Abel J, In J, Yin J, et al. Human enteroids as a model of upper small intestinal ion transport physiology and pathophysiology. Gastroenterology. 2016;150:638-49.

Terms in the title (6)： クローン病 ,  患者 ,  腸オルガノイド ,  シングルセル解析 ,  幹細胞性 ,  疾患活動性