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J-GLOBAL ID：201802283344511813   Reference number：18A1155053

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

筋萎縮性側索硬化症における変異Cu/Znスーパーオキシドジスムターゼの病理学的オリゴマーに関する免疫化学的特性化【JST・京大機械翻訳】

Author (11)： Tokuda Eiichi (Laboratory for Mechanistic Chemistry of Biomolecules, Department of Chemistry, Keio University, Yokohama, Japan) ,  Anzai Itsuki (Laboratory for Mechanistic Chemistry of Biomolecules, Department of Chemistry, Keio University, Yokohama, Japan) ,  Nomura Takao (Laboratory for Mechanistic Chemistry of Biomolecules, Department of Chemistry, Keio University, Yokohama, Japan) ,  Toichi Keisuke (Laboratory for Mechanistic Chemistry of Biomolecules, Department of Chemistry, Keio University, Yokohama, Japan) ,  Watanabe Masahiko (Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Ohara Shinji (Department of Neurology, Matsumoto Medical Center, Matsumoto, Japan) ,  Watanabe Seiji (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan) ,  Yamanaka Koji (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan) ,  Morisaki Yuta (Division of Pharmacology, Faculty of Pharmacy, Keio University, Tokyo, Japan) ,  Misawa Hidemi (Division of Pharmacology, Faculty of Pharmacy, Keio University, Tokyo, Japan) ,  Furukawa Yoshiaki (Laboratory for Mechanistic Chemistry of Biomolecules, Department of Chemistry, Keio University, Yokohama, Japan)
Material： Molecular Neurodegeneration (Web)
Volume： 12  Issue： 1  Page： 2  Publication year： 2017 
JST Material Number： U7339A  ISSN： 1750-1326  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background Dominant mutations ...

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Thesaurus term： transgenic mouse ,  disulfide bond ,  mutation ,  *amyotrophic lateral sclerosis ,  antibody ,  *superoxide dismutase ,  protein ,  *pathology ,  epitope ,  oligomerization ,  steric conformation ,  *variation(biology) ,  human(primates) ,  *oligomer ,  in vitro experiment

Author keywords (4)： Amyotrophic lateral sclerosis ,  Cu/Zn-superoxide dismutase ,  Protein misfolding ,  Disulfide bond

JST classification (4)： Enzyme physiology  (EJ02020P) ,  Enzyme in general  (EB09010D) ,  Nervous system diseases  (GN03000O) ,  Proteins and peptides in general  (EB03010N)

Reference (60)：

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• Hum Mutat.; ALSoD: A user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics; O Abel, JF Powell, PM Andersen, A Al-Chalabi; 33; 2012; 1345-1351; 10.1002/humu.22157; CR3;
• Nat Genet.; Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury; AG Reaume, JL Elliott, EK Hoffman, NW Kowall, RJ Ferrante, DF Siwek; 13; 1996; 43-47; 10.1038/ng0596-43; CR4;
• Science.; Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1; LI Bruijn, MK Houseweart, S Kato, KL Anderson, SD Anderson, E Ohama; 281; 1998; 1851-1854; 10.1126/science.281.5384.1851; CR5;

Terms in the title (9)： 筋萎縮性側索硬化症 ,  変異 ,  Cu ,  Zn ,  スーパーオキシドジスムターゼ ,  病理学 ,  オリゴマー ,  免疫 ,  化学的特性