Art
J-GLOBAL ID：201802284917625712   Reference number：18A0528992

Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury

薬物性肝障害を予測するためのグルタチオン欠乏HepaRGおよびHepG2ヒト肝細胞を用いた細胞基盤アッセイ【Powered by NICT】
Author (3)：
Xu Jieyu

About Xu Jieyu

(Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan)

About Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan

, 
Oda Shingo

About Oda Shingo

(Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan)

About Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan

, 
Yokoi Tsuyoshi

About Yokoi Tsuyoshi

(Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan)

About Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan


Material：
Toxicology in Vitro  (Toxicol Vitr)

About Toxicology in Vitro


Volume： 48  Page： 286-301  Publication year： 2018 
JST Material Number： T0472A  ISSN： 0887-2333  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
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Immortalized liver cells have ...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*HepG2 cell

About HepG2 cell

, 
cytotoxicity

About cytotoxicity

, 
toxicity

About toxicity

, 
drug metabolizing enzyme

About drug metabolizing enzyme

, 
*hepatocyte

About hepatocyte

, 
high sensitivity

About high sensitivity

, 
predictability

About predictability

, 
aliphatic amine

About aliphatic amine

, 
thiol

About thiol

, 
aliphatic carboxylic acid

About aliphatic carboxylic acid

, 
tripeptide

About tripeptide

, 
sulfur containing amino acid

About sulfur containing amino acid


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
創薬

About 創薬

, 
カスパーゼ3

About カスパーゼ3

, 
細胞生存率

About 細胞生存率

, 
HepaRG細胞

About HepaRG細胞

, 
*薬剤誘発性肝障害

About 薬剤誘発性肝障害

, 【Automatic Indexing@JST】
Author keywords (5)：
Cell-based assay

About Cell-based assay

, 
Drug-induced liver injury

About Drug-induced liver injury

, 
Glutathione

About Glutathione

, 
HepaRG

About HepaRG

, 
Reactive metabolites

About Reactive metabolites

JST classification (3)：
JST classification
Category name(code) classified by JST.
Toxicity of chemical substances in general 
(GZ02010C)

About Toxicity of chemical substances in general

,  Bioassay 
(EA03060N)

About Bioassay

,  Toxicology in general 
(GZ01000K)

About Toxicology in general

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
Glutathione

About Glutathione

Terms in the title (9)：
Terms in the title
Keywords automatically extracted from the title.
薬物性肝障害

About 薬物性肝障害

, 
予測

About 予測

, 
グルタチオン

About グルタチオン

, 
欠乏

About 欠乏

, 
HepG2

About HepG2

, 
ヒト肝細胞

About ヒト肝細胞

, 
細胞

About 細胞

, 
基盤

About 基盤

, 
アッセイ

About アッセイ


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