Art

J-GLOBAL ID：201802287006539359   Reference number：18A2166631

Ky-2, a hybrid compound histone deacetylase inhibitor, regulated inflammatory response in LPS-driven human macrophages

LPS駆動ヒトマクロファージにおけるハイブリッド複合ヒストン脱アセチル化酵素阻害剤,Ky-2は炎症反応を調節する【JST・京大機械翻訳】

Author (9)： Kaneko Junya (Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental University, Kitakyushu, Fukuoka, 803-8580, Japan) ,  Kaneko Junya (School of Oral Health Sciences, Kyushu Dental University, Kitakyushu, Fukuoka, 803-8580, Japan) ,  Okinaga Toshinori (Department of Bacteriology, Osaka Dental University, Hirakata, Osaka, 573-1121, Japan) ,  Ariyoshi Wataru (Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental University, Kitakyushu, Fukuoka, 803-8580, Japan) ,  Hikiji Hisako (Division of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University, Kitakyushu, Fukuoka, 803-8580, Japan) ,  Fujii Seiko (School of Oral Health Sciences, Kyushu Dental University, Kitakyushu, Fukuoka, 803-8580, Japan) ,  Iwanaga Kenjiro (Division of Preventive Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, 980-8575, Japan) ,  Tominaga Kazuhiro (School of Oral Health Sciences, Kyushu Dental University, Kitakyushu, Fukuoka, 803-8580, Japan) ,  Nishihara Tatsuji (Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental University, Kitakyushu, Fukuoka, 803-8580, Japan)
Material： Cell Biology International  (Cell Biol Int)
Volume： 42  Issue： 12  Page： 1622-1631  Publication year： 2018 
JST Material Number： T0950A  ISSN： 1065-6995  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Histone deacetylase has attrac...

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Thesaurus term： transcription factor ,  in vitro experiment ,  up-regulation ,  *acetylation ,  *human(primates) ,  interleukin 1 ,  histone deacetylase ,  gene expression ,  *macrophage ,  gene ,  *histone ,  polarization(phenomenon) ,  down-regulation ,  THP-1 cell
Semi thesaurus term： *炎症反応 , 【Automatic Indexing@JST】

Author keywords (5)： HDAC inhibitor ,  histone deacetylase ,  inflammasome ,  macrophage polarization ,  MAPK

JST classification (2)： Gene expression  (EC02040Q) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Terms in the title (4)： LPS ,  ヒストン脱アセチル化酵素阻害剤 ,  炎症反応 ,  調節