Art

J-GLOBAL ID：201802287622135253   Reference number：18A0013347

Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM

抗細菌IgMのソースとしての腹腔B-1a細胞の加齢関連欠損におけるZizimin2/3の関与

Author (5)： SAKAMOTO Akihiko (National Center for Geriatrics and Gerontology, Obu, JPN) ,  MATSUDA Takenori (National Center for Geriatrics and Gerontology, Obu, JPN) ,  KAWAGUCHI Koichiro (National Center for Geriatrics and Gerontology, Obu, JPN) ,  TAKAOKA Akinori (Hokkaido Univ., Sapporo, JPN) ,  MARUYAMA Mitsuo (National Center for Geriatrics and Gerontology, Obu, JPN)
Material： International Immunology  (Int Immunol)
Volume： 29  Issue： 9  Page： 431-438  Publication year： Sep. 2017 
JST Material Number： W0116A  ISSN： 0953-8178  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *immunoglobulin M ,...
Semi thesaurus term： IgM antibody ,...

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JST classification (2)： Biological function  (EB03040U) ,  Infectious immunity  (ED03030P)

Reference (27)：

• Nishikimi, A., Meller, N., Uekawa, N., Isobe, K., Schwartz, M. A. and Maruyama, M. 2005. Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett. 579:1039.
• Burbage, M., Keppler, S. J., Gasparrini, F. et al. 2015. Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity. J. Exp. Med. 212:53.
• Guo, F, Velu, C. S., Grimes, H. L. and Zheng, Y. 2009. Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood 114:2909.
• Matsuda, T., Yanase, S., Takaoka, A. and Maruyama, M. 2015. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. Immun. Ageing 12:1.
• Baumgarth, N. 2011. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat. Rev. Immunol. 11:34.

Terms in the title (6)： 抗細菌 ,  IgM ,  ソース ,  腹腔 ,  加齢 ,  欠損