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J-GLOBAL ID：201802288978816059   Reference number：18A1801458

S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy

S6k/p70s6k1はタウオパチーのショウジョウバエモデルにおいてSer262でリン酸化されたタウのレベルを低下させることによりタウ媒介神経変性から保護する【JST・京大機械翻訳】

Author (16)： Chiku Tomoki (Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Hayashishita Motoki (Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Saito Taro (Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Saito Taro (Department of Biological Sciences, Faculty of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Oka Mikiko (Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Shinno Kanako (Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Ohtake Yosuke (Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA) ,  Shimizu Sawako (Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Asada Akiko (Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Asada Akiko (Department of Biological Sciences, Faculty of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Hisanaga Shin-ichi (Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Hisanaga Shin-ichi (Department of Biological Sciences, Faculty of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Iijima Koichi M. (Department of Alzheimer’s Disease Research, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan) ,  Iijima Koichi M. (Department of Experimental Gerontology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan) ,  Ando Kanae (Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan) ,  Ando Kanae (Department of Biological Sciences, Faculty of Science, Tokyo Metropolitan University, Tokyo, Japan)
Material： Neurobiology of Aging  (Neurobiol Aging)
Volume： 71  Page： 255-264  Publication year： 2018 
JST Material Number： W0356A  ISSN： 0197-4580  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Abnormal accumulation of the m...

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Thesaurus term： toxicity ,  *phosphorylation ,  insulin ,  tau protein ,  microtubule ,  therapeutic planning ,  Autophagy ,  insulin receptor ,  insulin signaling ,  Gene Knockdown Technique ,  neuronal cell death ,  Neurodegenerative Diseases ,  *Drosophila ,  hypoglycemic drug ,  metabolic drug ,  carbohydrate metabolic drug ,  drug ,  *Diptera ,  *invertebrate
Semi thesaurus term： *Drosophila ,  *神経変性 ,  *タウオパチー , 【Automatic Indexing@JST】

Author keywords (6)： Tau ,  Neurodegeneration ,  Tau phosphorylation at Ser262 ,  S6K/p70S6K1 ,  Insulin signaling ,  Autophagy

JST classification (1)： Basic neurology  (GN01020W)

Terms in the title (6)： S6K ,  タウオパチー ,  ショウジョウバエ ,  モデル ,  リン酸化 ,  神経変性