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J-GLOBAL ID：201802289950971898   Reference number：18A1249618

Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells

突然変異p53発現細胞は隣接正常上皮細胞との細胞競合を介して壊死症を起こす【JST・京大機械翻訳】

Author (27)： Watanabe Hirotaka (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Watanabe Hirotaka (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan) ,  Ishibashi Kojiro (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Ishibashi Kojiro (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan) ,  Mano Hiroki (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Mano Hiroki (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan) ,  Kitamoto Sho (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Sato Nanami (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Sato Nanami (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan) ,  Hoshiba Kazuya (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Hoshiba Kazuya (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan) ,  Kato Mugihiko (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Matsuzawa Fumihiko (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Takeuchi Yasuto (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Shirai Takanobu (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Shirai Takanobu (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan) ,  Ishikawa Susumu (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Morioka Yuka (Division of Disease Model Innovation, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan) ,  Imagawa Toshiaki (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan) ,  Imagawa Toshiaki (Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan) ,  Sakaguchi Kazuyasu (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan) ,  Sakaguchi Kazuyasu (Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan) ,  Yonezawa Suguru (Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan) ,  Kon Shunsuke (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Kon Shunsuke (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan) ,  Fujita Yasuyuki (Division of Molecular Oncology, Hokkaido University, Sapporo 060-0815, Japan) ,  Fujita Yasuyuki (Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0815, Japan)
Material： Cell Reports
Volume： 23  Issue： 13  Page： 3721-3729  Publication year： 2018 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： p53 is a tumor suppressor prot...

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Thesaurus term： MDCK cell ,  carcinogenicity ,  carcinogenesis ,  *p53 protein ,  *necrosis ,  *variation(biology) ,  cell death ,  *epithelium ,  missense mutation ,  *mutation ,  human(primates) ,  *epithelial cell
Semi thesaurus term： 腫瘍進行 ,  ex vivo実験 ,  *細胞競合 , 【Automatic Indexing@JST】

Author keywords (9)： cell competition ,  p53 ,  necroptosis ,  p53R273H ,  p53R175H ,  RasV12 ,  multi-step cancer progression ,  MDCK cells ,  mouse intestinal organoids

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cell physiology in general  (EF02010S)

Terms in the title (7)： 突然変異 ,  p53 ,  発現 ,  細胞 ,  上皮細胞 ,  細胞競合 ,  壊死症