Art

J-GLOBAL ID：201802290348480207   Reference number：18A0990143

Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives

カチオン性プロリン誘導体を含む細胞透過性ペプチドの構造的開発

Author (9)： Kobayashi Hiroyuki (Division of Organic Chemistry, National Institute of Health Sciences) ,  Kobayashi Hiroyuki (Department of Chemistry and Life Science, Kogakuin University) ,  Misawa Takashi (Division of Organic Chemistry, National Institute of Health Sciences) ,  Oba Makoto (Graduate School of Biomedical Sciences, Nagasaki University) ,  Hirata Naoya (Division of Pharmacology, National Institute of Health Sciences) ,  Kanda Yasunari (Division of Pharmacology, National Institute of Health Sciences) ,  Tanaka Masakazu (Graduate School of Biomedical Sciences, Nagasaki University) ,  Matsuno Kenji (Department of Chemistry and Life Science, Kogakuin University) ,  Demizu Yosuke (Division of Organic Chemistry, National Institute of Health Sciences)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 66  Issue： 5  Page： 575-580(J-STAGE)  Publication year： 2018 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： peptide synthesis ,  *cell membrane ,  *membrane permeability ,  *oligopeptide ,  drug design ,  drug delivery system ,  imide ,  chain length effect ,  steric effect ,  DNA ,  plasmid
Semi thesaurus term： Guanidines ,  plasmid DNA ,  cell-penetrating peptide

Author keywords (8)： cell-penetrating peptide ,  cationic proline derivative ,  cellular environment ,  drug delivery system (DDS) carrier ,  cell-penetrating peptide ,  cationic proline derivative ,  cellular environment ,  drug delivery system (DDS) carrier

JST classification (1)： Peptides  (CF10080G)

Substance index (2)： (4R)-4β-Guanidino-L-proline ,  (4S)-4α-Guanidino-L-proline

Reference (19)：

• 1) Brooks H., Lebleu B., Vivès E., Adv. Drug Deliv. Rev., 57, 559-577 (2005).
• 2) Futaki S., Suzuki T., Ohashi W., Yagami T., Tanaka S., Ueda K., Sugiura Y., J. Biol. Chem., 276, 5836-5840 (2001).
• 3) Suzuki T., Futaki S., Niwa M., Tanaka S., Ueda K., Sugiura Y., J. Biol. Chem., 277, 2437-2443 (2002).
• 4) Rothbard J. B., Kreider E., VanDeusen C. L., Wright L., Wylie B. L., Wender P. A., J. Med. Chem., 45, 3612-3618 (2002).
• 5) Crisma M., Toniolo C., Biopolymers, 104, 46-64 (2015).

Terms in the title (4)： カチオン ,  プロリン誘導体 ,  細胞透過性ペプチド ,  開発