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J-GLOBAL ID：201802290710146650   Reference number：18A1646997

Establishment of a cell model of X-linked sideroblastic anemia using genome editing

ゲノム編集を用いたX連鎖鉄芽球性貧血の細胞モデルの確立【JST・京大機械翻訳】

Author (11)： Kaneko Kiriko (Department of Molecular Biochemistry, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan) ,  Kubota Yoshiko (Department of Molecular Biochemistry, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan) ,  Nomura Kazumi (Department of Molecular Biochemistry, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan) ,  Hayashimoto Haruka (Department of Molecular Biochemistry, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan) ,  Chida Taisei (Department of Molecular Biochemistry, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan) ,  Yoshino Naoto (Department of Microbiology, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan) ,  Wayama Marina (Science Systems Product Division, Science & Medical Systems Business Group, Hitachi High-Technologies Corporation) ,  Ogasawara Katsutoshi (Technical Support Center for Life Science Research, Iwate Medical University) ,  Nakamura Yukio (Cell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan) ,  Tooyama Ikuo (Molecular Neuroscience Research Center, Shiga University of Medical Science) ,  Furuyama Kazumichi (Department of Molecular Biochemistry, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan)
Material： Experimental Hematology  (Exp Hematol)
Volume： 65  Page： 57-68.e2  Publication year： 2018 
JST Material Number： T0591A  ISSN： 0301-472X  CODEN： EXHMA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： ALAS2 gene mutations cause X-l...

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Thesaurus term： ferritin ,  characterization ,  erythrocyte ,  stem cell ,  *Anemia ,  *Iron ,  differentiation (biology) ,  hemoglobin ,  human ,  Mitochondria ,  Mutation ,  axillary bud ,  in vitro experiment ,  mRNA ,  wild type

JST classification (5)： Cell physiology in general  (EF02010S) ,  Hematologic diagnosis  (GK02000Y) ,  Clinical hematology in general  (GK01030Y) ,  Erythrocytes  (EJ03020W) ,  Congenital diseases,deformities in general.  (GD03010V)

Terms in the title (3)： ゲノム編集 ,  鉄芽球性貧血 ,  細胞モデル