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J-GLOBAL ID：201802290737516423   Reference number：18A0331463

Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells

親油性トリフェニルホスホニウム誘導体は腫瘍細胞におけるミトコンドリアエネルギー代謝の阻害を介して放射線誘発細胞死を増強する【Powered by NICT】

Author (13)： Yasui Hironobu (Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan) ,  Yasui Hironobu (Central Institute of Isotope Science, Hokkaido University, Sapporo 060-0815, Japan) ,  Yamamoto Kumiko (Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan) ,  Suzuki Motofumi (Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan) ,  Sakai Yuri (Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan) ,  Bo Tomoki (Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan) ,  Nagane Masaki (Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan) ,  Nishimura Eri (Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan) ,  Yamamori Tohru (Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan) ,  Yamasaki Toshihide (Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan) ,  Yamada Ken-ichi (Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan) ,  Yamada Ken-ichi (Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan) ,  Inanami Osamu (Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan)
Material： Cancer Letters  (Cancer Lett)
Volume： 390  Page： 160-167  Publication year： 2017 
JST Material Number： E0606B  ISSN： 0304-3835  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： It has recently been reported ...

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Thesaurus term： radiosensitization ,  electron transport system ,  *tumor cell ,  *mitochondria ,  cytotoxicity ,  *tumor ,  cation ,  conjugation ,  A549 cell ,  *cell death ,  human(primates)
Semi thesaurus term： ミトコンドリア膜電位 ,  細胞生存 ,  *脂溶性 , 【Automatic Indexing@JST】

Author keywords (6)： ATP ,  Cancer ,  Mitochondria ,  Radiation ,  Reactive oxygen species ,  Triphenylphosphonium

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Triphenylphosphonium

Terms in the title (11)： 親油性 ,  トリフェニルホスホニウム ,  誘導体 ,  腫瘍細胞 ,  ミトコンドリア ,  エネルギー代謝 ,  阻害 ,  放射線 ,  誘発 ,  細胞死 ,  増強