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J-GLOBAL ID：201802291251097135   Reference number：18A1981102

The MAP3K2-ERK5 pathway upregulates cyclin D1 expression through histone H2A (Thr120) phosphorylation by VRK1

MAP3K2-ERK5経路はVRK1によるヒストンH2A(Thr120)のリン酸化を介してサイクリンD1発現を上方調節する

Author (9)： KATO Masanori (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  KATO Masanori (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  YONEDA Mitsuhiro (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  TAKESHIMA Yukio (Hiroshima Univ. Graduate School of Biomedical & Health Sci., Hiroshima, Japan.) ,  AMATYA Vishwa Jeet (Hiroshima Univ. Graduate School of Biomedical & Health Sci., Hiroshima, Japan.) ,  HIGASHI Miki (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  NAKAGAWA Takeya (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  ITO Takashi (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  ITO Takashi (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN)
Material： Acta Medica Nagasakiensia  (Acta Med Nagasaki Ensia)
Volume： 62  Issue： 1  Page： 15-26  Publication year： Oct. 2018 
JST Material Number： X0952A  ISSN： 0001-6055  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： HeLa cell ,...
Semi thesaurus term： ERK5 ,...

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JST classification (2)： Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Reference (39)：

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• 2. Huang W, Cui X, Chen Y , Shao M, Shao X, et al. (2016) High VRK1 expression contributes to cell proliferation and survival in hepatocellular carcinoma. Pathol Res Pract 212: 171-178.
• 3. Martin KJ, Patrick DR, Bissell MJ, Fournier MV (2008) Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS One 3: e2994.
• 4. Liu J, Wang Y , He S, Xu X, Huang Y , et al. (2016) Expression of vacciniarelated kinase 1 (VRK1) accelerates cell proliferation but overcomes cell adhesion mediated drug resistance (CAM-DR) in multiple myeloma. Hematology 21: 603-612.
• 5. Ben Z, Gong L, Qiu Y (2018) High expression of VRK1 is related to poor prognosis in glioma. Pathol Res Pract 214: 112-118.

Terms in the title (7)： ERK5 ,  経路 ,  ヒストンH2A ,  リン酸化 ,  サイクリンD1 ,  発現 ,  上方調節