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J-GLOBAL ID：201802291691401259   Reference number：18A0256328

PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions

PTP1B欠損は高脂肪食条件下でのAgRPのmRNA発現の減衰をもたらす視床下部インスリン感受性を改善する【Powered by NICT】

Author (14)： Sugiyama Mariko (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Banno Ryoichi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Mizoguchi Akira (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Tominaga Takashi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Tsunekawa Taku (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Onoue Takeshi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Hagiwara Daisuke (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Ito Yoshihiro (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Morishita Yoshiaki (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Iwama Shintaro (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Iwama Shintaro (Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-8601, Japan) ,  Goto Motomitsu (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Suga Hidetaka (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Arima Hiroshi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 488  Issue： 1  Page： 116-121  Publication year： 2017 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Hypothalamic insulin receptor ...

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Thesaurus term： Insulin resistance ,  *high fat diet ,  dephosphorylation ,  *Hypothalamus ,  phosphorylation ,  insulin receptor ,  Down-Regulation ,  *insulin ,  *mRNA ,  wild type ,  Akt/protein kinase B ,  insulin signaling ,  *mRNA expression ,  *Agouti-Related Protein ,  *protein tyrosine phosphatase-1B ,  *endocrine gland ,  *secretory gland ,  *hypoglycemic drug ,  *metabolic drug ,  *carbohydrate metabolic drug ,  *drug

Author keywords (4)： PTP1B ,  Insulin ,  Hypothalamus ,  AgRP

JST classification (2)： Cell physiology in general  (EF02010S) ,  Enzyme in general  (EB09010D)

Terms in the title (8)： PTP1B ,  欠損 ,  高脂肪食 ,  AgRP ,  mRNA発現 ,  減衰 ,  視床下部 ,  インスリン感受性