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J-GLOBAL ID：201802292531668666   Reference number：18A0718315

Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα

PPARαの分子会合モデルとその新しい特異的かつ効率的な配位子,ペマフィブラート SPPARMαの構造的基礎【JST・京大機械翻訳】

Author (26)： Yamamoto Yuta (Department of Chemistry, Rikkyo University, Nishi-Ikebukuro, Toshima, Tokyo 171-8501, Japan) ,  Takei Kenta (Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Arulmozhiraja Sundaram (Department of Chemistry, Rikkyo University, Nishi-Ikebukuro, Toshima, Tokyo 171-8501, Japan) ,  Arulmozhiraja Sundaram (Research Center for Smart Molecules, Rikkyo University, Nishi-Ikebukuro, Toshima, Tokyo 171-8501, Japan) ,  Sladek Vladimir (Department of Chemistry, Rikkyo University, Nishi-Ikebukuro, Toshima, Tokyo 171-8501, Japan) ,  Sladek Vladimir (Institute of Chemistry - Centre for Glycomics, Slovak Academy of Sciences, 845 38 Bratislava, Slovakia) ,  Sladek Vladimir (AMED-CREST, Japan Agency for Medical Research and Development, Chiyoda, Tokyo 100-0004, Japan) ,  Matsuo Naoya (Department of Chemistry, Rikkyo University, Nishi-Ikebukuro, Toshima, Tokyo 171-8501, Japan) ,  Han Song-iee (Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Matsuzaka Takashi (Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Matsuzaka Takashi (AMED-CREST, Japan Agency for Medical Research and Development, Chiyoda, Tokyo 100-0004, Japan) ,  Sekiya Motohiro (Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Sekiya Motohiro (AMED-CREST, Japan Agency for Medical Research and Development, Chiyoda, Tokyo 100-0004, Japan) ,  Tokiwa Takaki (Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8571, Japan) ,  Tokiwa Takaki (Department of Chemistry, Graduate School of Science, Tohoku University, Aramaki, Aoba, Sendai, Miyagi 980-8578, Japan) ,  Shoji Mitsuo (Center for Computational Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577, Japan) ,  Shigeta Yasuteru (Center for Computational Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577, Japan) ,  Nakagawa Yoshimi (Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nakagawa Yoshimi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Tokiwa Hiroaki (Department of Chemistry, Rikkyo University, Nishi-Ikebukuro, Toshima, Tokyo 171-8501, Japan) ,  Tokiwa Hiroaki (Research Center for Smart Molecules, Rikkyo University, Nishi-Ikebukuro, Toshima, Tokyo 171-8501, Japan) ,  Tokiwa Hiroaki (AMED-CREST, Japan Agency for Medical Research and Development, Chiyoda, Tokyo 100-0004, Japan) ,  Shimano Hitoshi (Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Shimano Hitoshi (AMED-CREST, Japan Agency for Medical Research and Development, Chiyoda, Tokyo 100-0004, Japan) ,  Shimano Hitoshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Shimano Hitoshi (Life Science Center, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba 305-8577, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 499  Issue： 2  Page： 239-245  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Peroxisome proliferator-activa...

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Thesaurus term： binding site ,  affinity ,  Proteins ,  human ,  interaction ,  luciferase ,  complex (substance) ,  homeostasis ,  steric conformation ,  *PPAR alpha ,  lipid ,  binding affinity ,  transcriptional activity ,  Ligands ,  *fibrate
Semi thesaurus term： *フィブラート , 【Automatic Indexing@JST】

Author keywords (6)： Peroxisome proliferator-activated receptors ,  Pemafibrate ,  Fenofibrate ,  Fragment molecular orbital theory ,  Luciferase assay ,  Protein-ligand interaction

JST classification (2)： Function of cell components  (EF03060C) ,  Gene expression  (EC02040Q)

Terms in the title (7)： PPARα ,  分子 ,  会合 ,  モデル ,  配位子 ,  ペマフィブラート ,  基礎