Art

J-GLOBAL ID：201802299382447038   Reference number：18A1495939

Preparation and Antiviral Activity of Some New C₃- and C_S-Symmetrical Tri-Substituted Triazine Derivatives Having Benzylamine Substituents

ベンジルアミン置換基を有するいくつかの新規のC₃-およびC_S-対称三置換トリアジン誘導体の調製と抗ウイルス活性

Author (13)： Mibu Nobuko (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Yokomizo Kazumi (Faculty of Pharmaceutical Sciences, Sojo University) ,  Sano Marina (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Kawaguchi Yuuna (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Morimoto Kenta (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Shimomura Syunsuke (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Sato Ryo (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Hiraga Nozomi (Faculty of Pharmaceutical Sciences, Sojo University) ,  Matsunaga Aya (Faculty of Pharmaceutical Sciences, Sojo University) ,  Zhou Jian-Rong (Faculty of Pharmaceutical Sciences, Sojo University) ,  Ohata Tomonori (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Aki Hatsumi (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Sumoto Kunihiro (Faculty of Pharmaceutical Sciences, Fukuoka University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 66  Issue： 8  Page： 830-838(J-STAGE)  Publication year： 2018 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *herpes simplex virus 1 ,...
Semi thesaurus term： median effective concentration ,...

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Author keywords (12)： 135-triazine ,  benzylamine-substituent ,  C₃-symmetry ,  anti-herpes simplex virus type 1 ,  hydrogen bond donor ,  structure-activity relationship ,  135-triazine ,  benzylamine-substituent ,  C₃-symmetry ,  anti-herpes simplex virus type 1 ,  hydrogen bond donor ,  structure-activity relationship

JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Triazines  (CF07107M)

Substance index (2)： N,N′,N′′-トリス(3,4-ジメトキシベンジル)-s-トリアジン-2,4,6-トリアミン ,  N2,N4-bis(2H-1,3-benzodioxol-5-ylmethyl)-6-isopropoxy-1,3,5-triazine-2,4-diamine

Reference (15)：

• 1) Clercq E. D., “Advances in Pharmacology Vol 67: Antiviral Agents,” Elsevier Academic Press, London, 2013, and related references cited therein.
• 2) Duran A. M., Meiler J., Comput. Struct. Biotechnol. J., 8, e201308004 (2013).
• 3) Contreras J.-M., Sippl W., “The Practice of Medicinal Chemistry” 3rd ed., ed. by Wermuth C. G., Elsevier Academic Press, London, 2008, pp. 380-414 and related references cited therein.
• 4) Mibu N., Yokomizo K., Koga A., Honda M., Mizokami K., Fujii H., Ota N., Yuzuriha A., Ishimaru K., Zhou J., Miyata T., Sumoto K., Chem. Pharm. Bull., 62, 1032-1040 (2014).
• 5) Mibu N., Yokomizo K., Yuzuriha A., Otsubo M., Kawaguchi Y., Sano M., Sakai I., Nakayama K., Zhou J.-R., Sumoto K., Heterocycles, 94, 1653-1677 (2017) and related references cited therein.

Terms in the title (9)： ベンジルアミン ,  置換基 ,  C3 ,  Cs ,  対称 ,  置換 ,  トリアジン誘導体 ,  調製 ,  抗ウイルス活性