Rchr
J-GLOBAL ID：201901000169512090
Update date: Mar. 02, 2026
OTSU WATARU
オオツ ワタル | OTSU WATARU
Affiliation and department：
Job title：
Research Assistant Professor
Homepage URL (1)：
https://bmrgpu.wixsite.com/website
Research field (3)：
Cell biology
, Pharmaceuticals - health and biochemistry
, Laboratory animal science
Research keywords (5)：
Macular degeneration
, Corneal epithelial cells
, Late endosome
, Macular dystrophy
, Membrane Trafficking
Papers (43)：
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Masaki Saito, Wataru Otsu, Kenichi Ishibashi, Gen-ichi Atsumi. The development of a methodology to measure primary ciliary length in neural progenitor cells with a target molecule knocked down. Biochemistry and Biophysics Reports. 2026
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Mayuna Obayashi, Wataru Otsu, Kanta Yamazaki, Shinsuke Nakamura, Hideaki Ishikawa, Yasuko Sakata, Makoto Tsuboi, Hideshi Tsusaki, Masamitsu Shimazawa. Pentadecyl, an Active Component of Microalgae, Ameliorates Endoplasmic Reticulum Stress and Blue Light-Induced Cell Death in Mouse Retina-Derived 661W Cells. Biological and Pharmaceutical Bulletin. 2025
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Emi Sugisawa, Wataru Otsu, Tomohiro Yako, Taketoshi Hata, Tomomi Morimoto, Hiroe Maruyama, Hiroyuki Kono, Shinsuke Nakamura, Hideshi Tsusaki, Masamitsu Shimazawa. Oral Administration of Heat-Killed Fructobacillus Fructosus FMO-85 Alleviates the Reduction in Tear Fluid in a Stress-Induced Dry Eye Mouse Model. BPB Reports. 2025
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Shohei Tsuji, Riku Hatano, Shinsuke Nakamura, Urara Kudo, Kota Aoshima, Honoka Fujimori, Yuya Takagi, Mayuna Obayashi, Takaaki Ito, Eriko Yamazoe, et al. Intranasal administration of liposomes: potential brain delivery with prospective ophthalmic reach. Journal of Drug Delivery Science and Technology. 2024
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Cheng Fu, Nan Yang, Jen-Zen Chuang, Nobuyuki Nakajima, Satoshi Iraha, Neeta Roy, Zhenquan Wu, Zhichun Jiang, Wataru Otsu, Roxana A. Radu, et al. Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration. Nature Communications. 2024
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MISC (3)：
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大津 航. 【一次繊毛研究から考える薬理学の新展開~細胞のアンテナの謎に迫る~】視細胞外節の特徴的な膜構造と膜タンパク質の繊毛輸送におけるエンドソーム経路の役割. 日本薬理学雑誌. 2024. 159. 4. 203-208
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大津 航. 【視覚障害の新たな治療法の開発を目指して】網膜の恒常性維持における細胞小器官とストレス応答機構の役割. ファルマシア. 2022. 58. 11. 1031-1035
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斎藤 将樹, 大津 航. 【シグナル受容器・一次繊毛を標的とした薬理学研究の展望】一次繊毛を介した細胞増殖の分子機構. 日本薬理学雑誌. 2019. 154. 4. 197-202
Books (1)：
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最新皮膚エイジングメカニズムと高機能性シワ改善化粧品の開発
シーエムシー出版 2020 ISBN:9784781315126
Lectures and oral presentations (5)：
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Investigation of the molecular mechanisms underlying outer segment transport in rodents using gene delivery systems
(The 48th Annual Meeting of the Molecular Biology Society of Japan 2025)
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Investigation of the role of Optineurin in maintaining membrane organelles in the retina
(APPW2025 (Anatomy-Physiology-Pharmacology Week in 2025) 2025)
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Role of membrane trafficking on the retinal homeostasis
(The 44th Annual Scientific Meeting of the Japanese Society for Ocular Pharmacology 2024)
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A new role of the late endosome in trafficking to the ciliary membrane
(JPW2022(Japan Basic and Clinical Pharmacology Week 2022) 2022)
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Role of subcellular organelles in the stress response to the environmental risk factors associated with Retinal degenerative diseases
(The 142nd Annual Meeting of the Pharmaceutical Society of Japan (Nagoya) 2022)
Education (2)：
- 2009 - 2013 Hokkaido University Graduate School of Veterinary Medicine
- 2003 - 2009 Hokkaido University Veterinary Medicine Veterinary Medicine
Professional career (2)：
- Ph.D. (Hokkaido University)
- DVM.
Work history (6)：
Committee career (2)：
- 2024/08 - 現在 Frontiers in Molecular Biosciences Current Advances in Primary and Motile Cilia Research for Developing New Medicine
- 2022/09 - 2023/10 Frontiers in Molecular Biosciences Primary Cilia as Therapeutic Targets
Awards (1)：
- 2009/05 - 日本膜学会 日本膜学会第31年会学生賞 赤血球型AE1の膜トラフィック:N末端領域ΦXΦXΦ配列によるER-Golgi間輸送制御
Association Membership(s) (4)：
The Japanese Society of Veterinary Science
, Japanese Society of Comparative and Veterinary Ophthalmology
, The Japanese Pharmacological Society
, Japanese Society for Ocular Pharmacology
