Aoe Tomohiko

Affiliation and department：

Research field (2)： Medical biochemistry , Anesthesiology

Research keywords (5)： anesthesia , pain , chaperone , protein quality control , ER stress

Research theme for competitive and other funds (28)：

2022 - 2025 ウイルス感染に関連する慢性疼痛疾患における中枢神経系の機能解析
2021 - 2024 オピオイド受容体細胞内情報伝達と小胞体ストレス
2017 - 2020 Pharmacological Chaperones Attenuate the Development of Opioid Tolerance
2013 - 2015 The effect of endoplasmic reticulum stress on neurotoxicity caused by inhalational anesthetics
2014 - 2015 麻酔薬の神経毒性における小胞体機能の影響

2012 - 2014 Pain treatment by using induced neuronal cell

2010 - 2012 The role of glial cell in cancer pain, for a new strategy of cancer pain.

2009 - 2011 化学シャペロンによる病態制御の検討

2008 - 2011 Molecular mechanisms for the development of morphine tolerance.

2008 - 2010 分子シャペロンの異常による小胞体ストレス病の解析

2005 - 2007 虚血・低酸素により誘導される新生期の脳障害への小胞体ストレス反応の関与の検討

2005 - 2006 小胞体分子シャペロン変異体ノックインマウスの解析

2005 - 2006 心不全に対する新たな治療法の開発

2004 - 2005 小胞体とゴルジ体間の小胞輸送の障害による心筋症発症機構の解明

2003 - 2005 Intracellular transport and molecular chaperone

2003 - 2005 Molecular mechanisms of the development of opioid tolerance in neuropathic pain model in mice.

2003 - 2004 KDEL受容体によるゴルジ体小胞体間の小胞輸送と蛋白質の成熟

2002 - 2003 小胞体ストレス反応の分子機構の解析

2001 - 2003 Development of New Guideline for the Theatment of Bone Cancer Pain.

2002 - 2002 哺乳類ポリコーム群による細胞増殖と細胞死制御の分子機序

2002 - 2002 KDEL受容体の障害による細胞内蛋白凝集の生成機序の検討

2001 - 2002 哺乳類ポリコーム群によるリンパ球機能のコントロール

2000 - 2002 The search for new therapeutic approaches to treating neuropathic pain

2001 - 2001 哺乳類ポリコーム群による細胞増殖と細胞死制御の分子機序

2000 - 2001 The KDEL receptor and vesicular traffic

1999 - 2000 A new approach for cellular injury

1999 - 2000 The development of a mouse model of neuropathic cancer pain

1999 - 1999 小胞体分子シャペロンによる細胞内蛋白質輸送の制御

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Papers (56)：

Ryoko Kawanaka, Hisayo Jin, Tomohiko Aoe. Unraveling the Connection: Pain and Endoplasmic Reticulum Stress. International journal of molecular sciences. 2024. 25. 9
Tomohiko Aoe, Ryoko Kawanaka, Fumio Ohsone, Akira Hara, Tokuzo Yokokawa. Functional connectivity associated with attention networks differs among subgroups of fibromyalgia patients: an observational case-control study. Scientific reports. 2024. 14. 1. 10197-10197
Ryoko Kawanaka, Shoko Sakuma, Hiroshi Kokubun, Shuhei Tetsu, Yugo Tagaito, Toshio Igarashi, Shan-Guang Liang, Tomohiko Aoe. Effects of Intraoperative Opioid Administration on Postoperative Pain and Pain Threshold: A Randomized Controlled Study. Journal of clinical medicine. 2022. 11. 19
Youta Okuyama, Hisayo Jin, Hiroshi Kokubun, Tomohiko Aoe. Pharmacological Chaperones Attenuate the Development of Opioid Tolerance. International Journal of Molecular Sciences. 2020. 21. 20. 7536-7536
Tomohiko Aoe. Pathological Aspects of COVID-19 as a Conformational Disease and the Use of Pharmacological Chaperones as a Potential Therapeutic Strategy. Frontiers in pharmacology. 2020. 11. 1095-1095

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MISC (102)：

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Lectures and oral presentations (3)：

ER chaperones regulate bidirectional transport between the ER and the Golgi complex through the KDEL receptor
(日本分子生物学会年会プログラム・講演要旨集 1998)
ER chaperones regulate bidirectional transport between the ER and the Golgi complex through the KDEL receptor
(日本分子生物学会年会プログラム・講演要旨集 1998)
担癌状態におけるRedox regulationとTCR複合体構造異常の解析
(日本分子生物学会年会プログラム・講演要旨集 1996)

Education (3)：

1991 - 1995 Chiba University Graduate School of Medicine
1981 - 1987 Chiba University School of Medicine
1978 - 1981 The University of Tokyo Faculty of Economics

Professional career (2)：

医学博士 (千葉大学)
医学士 (千葉大学)

Work history (1)：

2016/06 - 現在 Teikyo University Department of Medicine professor

Association Membership(s) (5)：

日本線維筋痛症・慢性痛学会 , The American Society of Anesthesiologists , The Biomedical Society for Stress Response, Japan , JAPAN SOCIETY OF PAIN CLINICIANS , JAPANESE SOCIETY OF ANESTHESIOLOGISTS

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