Rchr
J-GLOBAL ID：201901000515541646
Update date: Sep. 10, 2024
RYOSUKE NEGORO
ネゴロ リョウスケ | RYOSUKE NEGORO
Affiliation and department：
Job title：
Assistant Professor
Research field (3)：
Anatomy
, Clinical pharmacy
, Pharmaceuticals - health and biochemistry
Research keywords (1)：
Intestinal drug absorption, Intestinal drug metabolism, drug transporter, drug-metabolizing enzyme, iPS cells
Research theme for competitive and other funds (1)：
- 2021 - 2024 ゲノム編集技術を用いた消化管吸収・代謝・毒性を予測可能な腸管モデルの作製
Papers (17)：
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Ryosuke Negoro, Ayu Ouchi, Sayaka Deguchi, Kazuo Takayama, Takuya Fujita. Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System. Biological & pharmaceutical bulletin. 2024. 47. 8. 1422-1428
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Mengyang Wang, Yuko Sasaki, Rena Sakagami, Tomotaka Minamikawa, Masahiro Tsuda, Ryohei Ueno, Sayaka Deguchi, Ryosuke Negoro, Kanako So, Yuriko Higuchi, et al. Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs. ACS Biomaterials Science and Engineering. 2024
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Sayaka Deguchi, Kaori Kosugi, Rina Hashimoto, Ayaka Sakamoto, Masaki Yamamoto, Rafal P Krol, Peter Gee, Ryosuke Negoro, Takeshi Noda, Takuya Yamamoto, et al. Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips. PNAS nexus. 2023. 2. 3. pgad029
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Ryosuke Negoro, Mitsuki Tasaka, Sayaka Deguchi, Kazuo Takayama, Takuya Fujita. Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System. Cells. 2022. 11. 10
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Ryosuke Negoro, Naoki Yamada, Keita Watanabe, Yusuke Kono, Takuya Fujita. Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system. Archives of Toxicology. 2021
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Lectures and oral presentations (24)：
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炎症時の骨格筋に対して間葉系幹細胞が及ぼす影響に関する基礎的研究
(第69回日本薬学会関西支部総会・大会 2019)
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Caco-2 細胞におけるrhodamine123 の輸送特性に関する研究
(第69回日本薬学会関西支部総会・大会 2019)
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糖尿病発症時におけるNa+依存性クエン酸トランスポーターの発現変動に関する研究
(第69回日本薬学会関西支部総会・大会 2019)
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リポソームを用いた間葉系幹細胞の磁性化と機能評価の研究
(第69回日本薬学会関西支部総会・大会 2019)
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人工生体管デバイスを用いた消化管吸収への非撹拌水層の影響評価
(第69回日本薬学会関西支部総会・大会 2019)
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Education (2)：
- - 2019 Osaka University Graduate School of Pharmaceutical Sciences
- - 2015 Setsunan University. Faculty of Pharmaceutical Sciences
Professional career (1)：
- Doctor of Pharmacy (Osaka University)
Work history (1)：
- 2019/04/01 - 2024/03/31 Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences , Ritsumeikan University
Awards (2)：
- 2018/04 - 日本薬学会第138年会 学生優秀発表賞
- 2016/04 - 日本薬学会第136年会 学生優秀発表賞
Association Membership(s) (3)：
The International Society for Stem Cell Research
, The Japanese Society for the Study of Xenobiotics
, The Pharmaceutical Society of Japan
