2018 - 2020 A study on pathogenesis of depression by focusing on pathogenesis-specific reactive astrocytes
2016 - 2018 Study focusing on astrocyte-derived GDNF as a molecular basis of treatment-resistant depression.
2017 - アストロサイトLPA1受容体を標的とした抗うつ薬の新たな薬理作用の解明
2012 - 2015 アストロサイトを標的とした抗うつ薬の新規薬理作用に関する研究
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Papers (29):
Kotaro Miyako, Naoto Kajitani, Yusaku Koga, Hitoshi Takizawa, Shuken Boku, Minoru Takebayashi. Identification of the antidepressant effect of electroconvulsive stimulation-related genes in hippocampal astrocyte. Journal of Psychiatric Research. 2024. 170. 318-327
Yusaku Koga, Naoto Kajitani, Kotaro Miyako, Hitoshi Takizawa, Shuken Boku, Minoru Takebayashi. TCF7L2: A potential key regulator of antidepressant effects on hippocampal astrocytes in depression model mice. Journal of Psychiatric Research. 2024. 170. 375-386
Masaru Uragami, Kozo Matsushita, Yuto Shibata, Shu Takata, Tatsuki Karasugi, Takanao Sueyoshi, Tetsuro Masuda, Takayuki Nakamura, Takuya Tokunaga, Satoshi Hisanaga, et al. A machine learning-based scoring system and ten factors associated with hip fracture occurrence in the elderly. Bone. 2023. 176. 116865-116865
Naoto Kajitani, Mami Okada-Tsuchioka, Asuka Inoue, Kanako Miyano, Takeshi Masuda, Shuken Boku, Kazuya Iwamoto, Sumio Ohtsuki, Yasuhito Uezono, Junken Aoki, et al. G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023
Hiromi Abe, Mami Okada-Tsuchioka, Naoto Kajitani, Wataru Omori, Kei Itagaki, Chiyo Shibasaki, Shuken Boku, Tetsuaki Matsuhisa, Minoru Takebayashi. Serum levels of high mobility group box-1 protein (HMGB1) and soluble receptors of advanced glycation end-products (RAGE) in depressed patients treated with electroconvulsive therapy. Neuropsychopharmacology reports. 2023