Naoto Kajitani

カジタニナオト | Naoto Kajitani

Affiliation and department：
Homepage URL (1)： https://matsuinobuyuu.wixsite.com/mysite

Research field (4)： Psychiatry , Nutrition and health science , Hygiene and public health (non-laboratory) , Molecular biology

Research keywords (7)：予防医学 , コホート研究 , プロテオミクス , 神経精神薬理学 , 抗うつ薬 , LPA1受容体 , アストロサイト

Research theme for competitive and other funds (13)：

2026 - 2028 魚由来成分DHA-LPCを用いた治療抵抗性うつ病の治療戦略の開発
2025 - 2028 Elucidating the molecular and cellular mechanisms of emotional behavior modulation by LPAR1-biased agonists
2023 - 2027 Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressants
2024 - 2025 認知症予防のための新たなバイオマーカーの確立と評価
2022 - 2025 海馬アストロサイトに着目した電気けいれん療法の作用機序解明

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Papers (37)：

Kazuhiro Yoshiura, Yosuke Hidaka, Takashi Suehiro, Naoto Kajitani, Asuka Koyama, Yusuke Miyagawa, Naoko Tsunoda, Tomohisa Ishikawa, Ryuji Fukuhara, Mamoru Hashimoto, et al. Association between cerebrospinal fluid volume and frailty in community-dwelling older adults: a cross-sectional study. Fluids and barriers of the CNS. 2026
Maiko Nagaoka, Katsuya Nagaoka, Naoto Kajitani, Kazuhiro Yoshiura, Yoko Yoshimaru, Takehisa Watanabe, Hiroko Setoyama, Noboru Fujise, Minoru Takebayashi, Yasuhito Tanaka. The Role of an Elevated Fibrosis-4 Index in Neurocognitive Decline and Brain Volume Reduction in Older Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease. Geriatrics & gerontology international. 2025. 25. 12. 1903-1910
Yuki Jimbayashi Kutsuna, Nozomi Aibara, Junya Hashizume, Wataru Omori, Mami Okada-Tsuchioka, Naoto Kajitani, Mikiro Nakashima, Atsushi Kawakami, Kaname Ohyama, Minoru Takebayashi. Identification of shared pathophysiological molecules of major psychiatric disorders: A comprehensive analysis of serum immune complex antigens before and after electroconvulsive therapy. JOURNAL OF NEUROIMMUNOLOGY. 2025. 405. 578623-578623
Maiko Nagaoka, Katsuya Nagaoka, Naoto Kajitani, Seiji Yuki, Asuka Koyama, Kazuhiro Yoshiura, Kazuki Honda, Yusuke Miyagawa, Shuken Boku, Noboru Fujise, et al. The mediating role of instrumental activities of daily living between cognitive function and depressive symptoms in community-dwelling older adults: the Arao study. BMC PSYCHIATRY. 2025. 25. 1. 674-674
Keisuke Takahashi, Katsumasa Ideo, Masaru Uragami, Yuko Fukuma, Takehiro Koga, Kazuhiro Yoshiura, Shuken Boku, Naoto Kajitani, Minoru Takebayashi, Takeshi Miyamoto. A scoring system and seven factors associated with certification for Japanese long-term care insurance in older people. JOURNAL OF BONE AND MINERAL METABOLISM. 2025. 43. 4. 419-429

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MISC (43)：

石本太我, 高月真彩留, 徐書誠, 梶谷直人, 近藤邦生, 竹林実, 戸田知得. The Role of the Fastigial Nucleus in the Impairment of Systemic Glucose Metabolism in Chronic Stress. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2025. 130th
朴秀賢, 都剛太郎, 梶谷直人, 竹林実. 【病態生理仮説が切り開くうつ病治療の未来】ECTの作用機序へのアストロサイトの関与とその背景に存在する分子メカニズムの検討. 臨床精神薬理. 2024. 27. 7. 685-690
梶谷直人. うつ病の新しい治療ターゲットHippo経路の解明. 先進医薬研究振興財団研究成果報告集. 2024. 2023年度. 86-87
梶谷直人, 梶谷直人, 梶谷直人. 抗うつ薬の新規薬理作用からうつ病の病態メカニズムを考える~マウスとヒトを使った研究~. 日本うつ病学会総会プログラム・抄録集. 2024. 21st
竹林実, 梶谷直人. Drug repositioning of antidepressants: The potential of LPA1 receptors as a novel therapeutic target. 月刊細胞. 2024. 56. 13

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Books (2)：

精神科治療学第40巻増刊号〈特集〉うつ病 123のQ&A
星和書店 2025
「医学のあゆみ」第5土曜特集第292巻13号脳科学研究が推進するうつ病の病態・診断・治療の発展
医歯薬出版株式会社 2025

Lectures and oral presentations (7)：

三環系抗うつ薬は SSRI よりも治療効果が強いのか?
(情動研究会 2024 2024)
抗うつ薬の新規薬理作用からうつ病の病態メカニズムを考える~マウスとヒトを使った研究~
(第21回日本うつ病学会総会 2024)
Prototypic antidepressants act as a G protein-biased LPAR1 agonist and contribute to antidepressant effects
(CINP2024 2024)
Tricyclic antidepressants act as a G protein-biased LPA1 receptor agonist and contribute to antidepressant effects
(2023)
Lysophosphatidic acid receptor 1 in astrocytes as a therapeutic target for depression
(Naito Conference 2023 2023)

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Education (3)：

2012 - 2015 Hiroshima University Graduate School of Biomedical Sciences
2010 - 2012 Hiroshima University
2006 - 2010 Hiroshima University Faculty of Pharmaceutical Sciences Institute of Medicinal Sciences

Professional career (1)：

博士(薬科学) (広島大学)

Work history (5)：

2025/06 - 現在熊本大学大学院生命科学研究部付属健康長寿代謝制御研究センター精神病態医学講座助教
2022/06 - 2025/05 Kumamoto University Center for Metabolic Regulation of Healthy Aging
2020/01 - 2022/05 Kumamoto University Faculty of Life Sciences
2015/04 - 2019/12 国立病院機構呉医療センター・中国がんセンター臨床研究部研究員
2012/04 - 2015/03 日本学術振興会特別研究員(DC1)

Committee career (1)：

2017 - 2020/03 日本薬学会薬理系薬学部会若手世話人

Awards (2)：

2024/05 - JSNP JSNP Excellent Presentation Award for CINP 2024
2011/09 - JSNP JSNP Excellent Presentation Award for AsCNP 2011

Association Membership(s) (5)：

日本老年医学会 , 日本生物学的精神医学会 , 日本神経精神薬理学会 , Society for neuroscience , THE PHARMACEUTICAL SOCIETY OF JAPAN

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