Rchr
J-GLOBAL ID：201901000571237798   Update date: Sep. 19, 2024

Osaki Tsukasa

Osaki Tsukasa
Affiliation and department：
Yamagata University Faculty of Medicine School of Medicine Department of Molecular Patho-Biochemistry and Patho-Biology

About Yamagata University Faculty of Medicine School of Medicine Department of Molecular Patho-Biochemistry and Patho-Biology


Job title： Assistant Professor
Research field  (2)： Other ,  Medical biochemistry
Research keywords  (1)： Thrombosis and Haemostasis
Research theme for competitive and other funds  (23)：
  • 2018 - 2021 自己免疫性出血症治療の「均てん化」のための実態調査と「総合的」診療指針の作成
  • 2016 - 2019 Molecular pathology of autoimmune hemorrhaphilia XIII/13; analysis of anti-factor XIII autoantibodies and elucidation of the mechanism of their generation
  • 2015 - 2018 Molecular mechanism elucidation of alternative fibrin degradation pathway aiming for diagnosis and treatment of plasminogen deficiency
  • 2015 - 2018 自己免疫性出血症治療の「均てん化」のための実態調査と「総合的」診療指針の作成
  • 2015 - 2018 プラスミノゲン欠損症の診断・治療を目指した代替的フィブリン分解経路の分子機構解明
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Papers (102)：
  • Yusuke Murakami, Mitsuhiro Nishigori, Hiroaki Yagi, Tsukasa Osaki, Masaki Wakabayashi, Manabu Shirai, Cheol Son, Yutaka Iba, Kenji Minatoya, Kengo Kusano, et al. Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D. Proteome Science. 2023. 21. 1
  • Tsukasa Osaki, Masayoshi Souri, Chikako Yokoyama, Yasuo Magari, Akitada Ichinose. Unmet Need for Reliable Immunological Detection Method for Anti-von Willebrand Factor Autoantibodies. Thrombosis and haemostasis. 2023. 123. 4. 478-481
  • Tsukasa Osaki, Chikako Yokoyama, Yasuo Magari, Masayoshi Souri, Akitada Ichinose. Novel immunochromatographic test for anti-factor XIII B subunit autoantibodies to diagnose autoimmune acquired factor XIII deficiency. Thrombosis and haemostasis. 2023
  • Tsukasa Osaki, Masayoshi Souri, Tatsuhiko Ozawa, Atsushi Muraguchi, Akitada Ichinose. Epitope analysis of human monoclonal antibodies from a patient with autoimmune factor XIII deficiency reveals their inhibitory mechanisms. FEBS Letters. 2023. 597. 9. 1275-1289
  • Masayoshi Souri, Chikako Yokoyama, Tsukasa Osaki, Akitada Ichinose. Antibodies against non-catalytic B subunit of factor XIII inhibit activation of factor XIII and fibrin crosslinking. Thrombosis and haemostasis. 2023
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MISC (152)：
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Patents (3)：
  • 抗第XIII/13因子Aサブユニットに対するIgM又はIgA型抗体検出法
  • 抗第XIII/13因子Bサブユニット抗体検出法
  • ペプチド及びその用途
Books (1)：
  • Current views of activating and regulatory mechanisms of blood coagulation
    Nihon Rinsho 2014
Lectures and oral presentations  (73)：
  • タンパク質架橋化反応から展開する医療と創薬へ向けた基礎研究 細胞内凝固第XIII因子(血漿トランスグルタミナーゼ)の役割
    (日本生化学会大会プログラム・講演要旨集)
  • 線溶亢進型DICを合併した自己免疫性後天性凝固第V因子欠乏症
    (日本検査血液学会雑誌 2020)
  • 自己免疫性第XIII因子欠乏症における自己抗体の消失について
    (日本血栓止血学会誌 2020)
  • 自己免疫性後天性凝固因子欠乏症の血漿プロテオーム解析
    (日本血栓止血学会誌 2020)
  • 経時的な抗FXIII自己抗体の測定をガイドとして治療を遂行した自己免疫性凝固第XIII因子欠乏症例
    (日本血栓止血学会誌 2020)
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Education (3)：
  • 1999 - 2002 Kyushu University
  • 1997 - 1999 Kyushu University
  • 1993 - 1997 Kyushu University School of Sciences
Work history (8)：
  • 2021/05 - 現在 Faculty of Medicine, Yamagata University
  • 2017/10 - 2021/04 Faculty of Medicine, Yamagata University
  • 2012/04 - 2017/09 Yamagata University Faculty of Medicine School of Medicine Department of Molecular Patho-Biochemistry and Patho-Biology Assistant Professor
  • 2011/01 - 2012/03 National Cerebral and Cardiovascular Center, Research Institute
  • 2006/01 - 2010/12 国立循環器病センター研究所 薬理部 室員
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Awards (1)：
  • 2014/10 - トランスグルタミナーゼ研究会 Young Investigator Award 2014 Characterization of plasma pro-transglutaminase, coagulation factor XIII, using its synthetic peptides
Association Membership(s) (3)：
THE JAPANESE SOCIETY OF HEMATOLOGY ,  THE JAPANESE SOCIETY ON THROMBOSIS AND HEMOSTASIS ,  THE JAPANESE BIOCHEMICAL SOCIETY
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