2017 - 2020 Basic study for preeclampsia therapeutics by phosphodiesterase-5 inhibitor
2015 - 2019 An approach to pathological analysis of fetal and neonatal brain damage from the viewpoint of brain development (six layers of cerebrum)
2015 - 2018 In utero Immune tolerance induction for Severe Congenital skin diseases
2014 - 2017 Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening.
2014 - 2017 The management of labor and fetal cerebral oxygenation: the importance of carbon dioxide
2014 - 2017 Reconstitution of gynecological cancer microenvirnment
2014 - 2017 Prevention and Classification of recurrent preterm birth using a standard protocol: A prospective multicenter study
2012 - 2015 Exploit of new strategy of prediction, prevention, treatment of preeclampsia using
2012 - 2015 The regulation mechanism of uterine contraction: Association between Uterine myometrium and Immunological cells/oxidative stress
2011 - 2013 A trial of the establishment of the umbilical cord blood stem cell transplantation for the neonatal brain injury: a search for the effective transplantation -
2010 - 2012 The involvement of thyroid hormones and related molecules in neuroprotective mechanisms in the developing brain.
2011 - 新生児脳障害に特異的な病態の解明~胎児脳における甲状腺ホルモン関連分子の重要性~
2008 - 2010 Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage
2008 - 2010 The new treatment strategy for the perinatal brain damage with the mesenchymal stem cell derived from fetal appendages
2007 - 2008 Treatment and prevention for perinatal brain injury, based on the specific mechanism for immature brain
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Papers (368)：
Reina Komatsu, Hitomi Nakamura, Kazunobu Yagi, Kazuya Mimura, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura, Michiko Kodama. The role of beta-2-glucoprotein I during pregnancy. Journal of Reproductive Immunology. 2025. 172. 104767-104767
Reina Komatsu, Kazunobu Yagi, Hitomi Nakamura, Mari Tabuse, Yoshitomo Tanaka, Kazuya Mimura, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura, Michiko Kodama. Beta2-glycoprotein I: More than just antibodies, physiological significance in pregnancy. Placenta. 2025. 169. 145-145
Kazunobu Yagi, Reina Komatsu, Hitomi Nakamura, Kazuya Mimura, Masayuki Endo, Takuji Tomimatsu, Tadashi Kimura. Beyond antibodies: Beta-2 glycoprotein I as the unsung guardian of pregnancy. PloS one. 2025. 20. 4. e0321405
Hitomi Nakamura, Kazunobu Yagi, Reina Komatsu, Kazuya Mimura, Mari Tabuse, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura. Physiological function of beta 2 glycoprotein I in placenta. Placenta. 2024. 154. e19-e19
Reina Komatsu, Kazuya Mimura, Tatsuya Matsuyama, Yoko Kawanishi, Hitomi Nakamura, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura. Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan. The journal of obstetrics and gynaecology research. 2024
